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Lab Manual for UCSF Clinical Laboratories

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Item Value
Available Stat? No
Test code MOLT
Performed by ARUP
Sendout? Yes
In House Availability Run 1-2 times per week as needed
Method Fluorescent in-situ hybridization (FISH)
Collection Instructions For UCSF Samples (from remote sites) Click here for sample collection instructions

For NON-UCSF Samples Click here for Requisition form & Account set-up instructions. Note we only do institutional billing.
Container type
Sample type Formalin-fixed, paraffin-embedded tissue on three (3) unstained slides (5 microns thick) on charged glass. One adjacent hematoxylin and eosin stained (H&E) slide should also be included. Slides should be labeled with pathology case number and block identification.
Preferred volume 3 unstained slides
Min. Volume 1 unstained slides
UCSF Rejection Criteria All required slides not included. Insufficient tumor present on slide as determined by pathologist. Slides not labeled or not accompanied by completed requisition form.
Units Percentage of cells with break-apart signals
Normal range <10%
Synonyms SYT
Stability Slides are stable indefinitely at room temperature
Turn around times 10-14 days
Additional information An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.

SS18 (SYT) gene rearrangement testing by FISH is designed to detect the translocations of SS18 gene in sarcomas. This feature is seen in synovial sarcoma.

The clinical interpretation of this test should be evaluated within the context of the patient's medical history, other diagnostic tests, and the histologic and immunohistochemical features of the tumor.

The test was validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
CPT coding 88377-90
LDT or Mod FDA? Yes
Last Updated 12/22/2015 3:23:54 PM
Entry Number 1480
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