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|Collection Instructions||Do NOT use serum separator tube. Optimum time to collect sample: 10-14 hours post oral dose. For best analytical sensitivity, please submit greater than or equal to the published minimum volume|
|Container type||Red top or Lavender top (Gold top NOT acceptable)|
|Amount to Collect||8 mL blood|
|Sample type||Serum or EDTA plasma|
|Preferred volume||4 mL serum or plasma|
|Min. Volume||2 mL serum or plasma|
|UCSF Rejection Criteria||Collected in Gold top or grossly hemolyzed. Samples with less than 1/2 the published minimum volume.|
|Processing notes||Separate plasma or serum promptly and freeze at -20C. Specimen must be kept frozen. Order Order Quest #8592X|
|Normal range||25-100 ng/mL|
|Turn around times||Test performed Monday-Saturday. Turnaround time: 1-3 days.|
|Additional information||Because of unavailability of a pure reference preparation, the hydroxymetabolite is no longer reported.
Clinical use: Buproprion is used to treat patients with depression. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. Maximum antidepressant response observed at trough plasma concentrations of 50-100 ng/ml with virtually no response below 25 ng/ml.
If the volume of sample submitted is at least 1/2 the published minimum volume, this assay will be performed on a 1:2 dilution of the sample. Following dilution, lower levels of this drug will not be detected due to a two-fold decrease in analytical sensitivity.
|Last Updated||10/28/2013 11:48:26 AM|