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Bupropion

Item Value
Approval req'd? No
Available Stat? No
Test code BUPR
Performed by Quest
Sendout? Yes
Method HPLC
Collection Instructions Do NOT use serum separator tube. Optimum time to collect sample: 10-14 hours post oral dose. For best analytical sensitivity, please submit greater than or equal to the published minimum volume
Container type Red top or Lavender top (Gold top NOT acceptable)
Amount to Collect 8 mL blood
Sample type Serum or EDTA plasma
Preferred volume 4 mL serum or plasma
Min. Volume 2 mL serum or plasma
UCSF Rejection Criteria Collected in Gold top or grossly hemolyzed. Samples with less than 1/2 the published minimum volume.
Processing notes Separate plasma or serum promptly and freeze at -20C. Specimen must be kept frozen. Order Order Quest #8592X
Units ng/mL
Normal range 25-100 ng/mL
Synonyms Wellbutrin
Turn around times Test performed Monday-Saturday. Turnaround time: 1-3 days.
Additional information Because of unavailability of a pure reference preparation, the hydroxymetabolite is no longer reported.

Clinical use: Buproprion is used to treat patients with depression. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. Maximum antidepressant response observed at trough plasma concentrations of 50-100 ng/ml with virtually no response below 25 ng/ml.

If the volume of sample submitted is at least 1/2 the published minimum volume, this assay will be performed on a 1:2 dilution of the sample. Following dilution, lower levels of this drug will not be detected due to a two-fold decrease in analytical sensitivity.
CPT coding 80299-90
LOINC code 6706-6
Last Updated 10/28/2013 11:48:26 AM
Entry Number 145
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