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Isochrome 17q FISH
|Test group||Oncology FISH|
|Performed by||Clinical Cancer Genomics Laboratory (CCGL)|
|In House Availability||Run 2x per week, Monday & Wednesday, day shift only|
|Method||Fluorescent in-situ hybridization (FISH)|
|Collection Instructions||For UCSF Samples (from remote sites) Click here for sample collection instructions
For NON-UCSF Samples Click here for Requisition form & Account set-up instructions. Note we only do institutional billing.
|Sample type||Formalin-fixed, paraffin-embedded tissue on three (3) unstained, charged, glass slides (5 microns thick) . One adjacent hematoxylin and eosin stained (H&E) slide should also be included. Slides should be labeled with pathology case number and block identification.|
|Preferred volume||3 unstained slides (5 micron thick sections)|
|Min. Volume||1 unstained slide (5 micron thick section)|
|UCSF Rejection Criteria||All required slides not included. Insufficient tumor present on slide as determined by pathologist. Slides not labeled or not accompanied by completed requisition form.|
|Units||Ratio of 17q to 17p signals; %17p deleted cells; %Isochromosome 17q cells|
|Stability||Slides are stable indefinitely at room temperature|
|Turn around times||10-14 days|
|Additional information||An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.
Isochromosome 17q testing by FISH is designed to identify isochromosome involving the chromosome 17 long (q) arm or deletion of chromosome 17 short (p) arm in tumors. Isochromosome 17q is associated with poor prognosis in Medulloblastoma.
The clinical interpretation of this test should be evaluated within the context of the patient's medical history, other diagnostic tests, and the histologic and immunohistochemical features of the tumor.
The test was validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
|CPT coding||88368 x2|
|LDT or Mod FDA?||Yes|
|Last Updated||12/3/2015 12:45:17 PM|