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Isochrome 17q FISH

Item Value
Available Stat? No
Test code
Test group Oncology FISH
Performed by Clinical Cancer Genomics Laboratory (CCGL)
In House Availability Run 2x per week, Monday & Wednesday, day shift only
Method Fluorescent in-situ hybridization (FISH)
Collection Instructions For UCSF Samples (from remote sites) Click here for sample collection instructions

For NON-UCSF Samples Click here for Requisition form & Account set-up instructions. Note we only do institutional billing.
Container type
Sample type Formalin-fixed, paraffin-embedded tissue on three (3) unstained, charged, glass slides (5 microns thick) . One adjacent hematoxylin and eosin stained (H&E) slide should also be included. Slides should be labeled with pathology case number and block identification.
Preferred volume 3 unstained slides (5 micron thick sections)
Min. Volume 1 unstained slide (5 micron thick section)
UCSF Rejection Criteria All required slides not included. Insufficient tumor present on slide as determined by pathologist. Slides not labeled or not accompanied by completed requisition form.
Units Ratio of 17q to 17p signals; %17p deleted cells; %Isochromosome 17q cells
Normal range
17p:17q 0.97 +/- 0.07
%17p deleted cells < 20%
%isochromosome 17q cells <2%
Synonyms ISO17q; Iso17q
Stability Slides are stable indefinitely at room temperature
Turn around times 10-14 days
Additional information An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.

Isochromosome 17q testing by FISH is designed to identify isochromosome involving the chromosome 17 long (q) arm or deletion of chromosome 17 short (p) arm in tumors. Isochromosome 17q is associated with poor prognosis in Medulloblastoma.

The clinical interpretation of this test should be evaluated within the context of the patient's medical history, other diagnostic tests, and the histologic and immunohistochemical features of the tumor.

The test was validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
CPT coding 88368 x2
LDT or Mod FDA? Yes
Last Updated 12/3/2015 12:45:17 PM
Entry Number 1435
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