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Paraneoplastic Antibody Evaluation, Serum (New test)

Item Value
Approval req'd? No
Available Stat? No
Test code PAE
Test group Paraneoplastic antibodies
Performed by Mayo
Sendout? Yes
Method IFA, RIA, EIA
Container type Red top, Gold top
Amount to Collect 6 mL blood
Sample type Serum
Preferred volume 3 mL serum
Min. Volume 2 mL serum
Processing notes Refrigerate serum and ship to China Basin refrigerated. Do not freeze. Should be shipped same day as collection.
Units Titer
Normal range
Antibody Titer
Antineuronal Nuclear Antibody-Type 1 (ANNA-1) <1:240

Antineuronal Nuclear Antibody -Type 2 (ANNA-2) <1:240
Antineuronal Nuclear Antibody -Type 3 (ANNA-3) <1:240
Anti-Glial/Neuronal Nuclear Antibody-Type 1 (AGNA-1) <1:240
Purkinje Cell Cytoplasmic Antibody, Type 1 (PCA-1) <1:240
Purkinje Cell Cytoplasmic Antibody, Type 2 (PCA-2) <1:240
Purkinje Cell Cytoplasmic Antibody, Type Tr (PCA-Tr) <1:240
Amphiphysin Antibody <1:240
CRMP-5-IgG <1:240*
Striational (Striated Muscle) Antibodies <1:60
N-Type Calcium Channel Antibody ≤ 0.03 nmol/L
P/Q-Type Calcium Channel Antibody ≤ 0.02 nmol/L
ACh Receptor (Muscle) Binding Antibody ≤ 0.02 nmol/L
AChR Ganglionic Neuronal Antibody ≤ 0.02 nmol/L
Neuronal VGKC Autoantibody ≤ 0.02 nmol/L


*Note: Titers lower than 1:240 are detectable by recombinant CRMP-5 Western blot analysis. CRMP-5 Western blot analysis will be done on request on stored serum (held 4 weeks). This supplemental testing is recommended in cases of chorea, vision loss, cranial neuropathy, and myelopathy. Call the Neuroimmunology Laboratory at 800-533-1710 or 507-266-5700 to request CRMP-5 Western blot.

Neuron-restricted patterns of IgG staining that do not fulfill criteria for amphiphysin, ANNA-1, ANNA-2, ANNA-3, AGNA-1, PCA-1, PCA-2, PCA-Tr, or CRMP-5-IgG may be reported as "unclassified antineuronal IgG." Complex patterns that include non-neuronal elements may be reported as "uninterpretable."
Synonyms Antineuronal Nuclear Antibody-Type 1; ANNA-1; Antineuronal Nuclear Antibody-Type 2; ANNA-2; Antineuronal Nuclear Antibody-Type 3; ANNA-3; Anti-Glial/neuronal Nuclear Antibody-Type 1; AGNA-1; Purkinje Cell Cytoplasmic Antibody-Type 1; PCA-1; Purkinje Cell Cytoplasmic Antibody-Type 2; PCA-2; Purkinje Cell Cytoplasmic Antibody-Type Tr; PCA-Tr; Amphiphysin Antibody; CRMP-5-IgG
Stability Room temperature 3 days, refrigerated or frozen 4 weeks.
Turn around times 3-4 weeks
Last Updated 7/29/2014 12:24:06 PM
Entry Number 1423
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