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Lab Manual for Moffitt-Long and Mount Zion

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Botulism Toxin, Adults and Children > 12 months old

Item Value
Approval req'd? Patient's physician must discuss the case and receive approval for submission of specimens from the SF Department of Public Health Communicable Disease Control Unit (415) 554-2830, 24 hours/day, 7 days/wk. The patient's physician will then be contacted by the State Communicable Disease Control Duty Officer of the Day for approval PRIOR to submission of specimens.
Available Stat? No
Test code P319
Test group Botulism
Performed by California State Public Health Reference Laboratory
Sendout? Yes
In House Availability Sent out Monday-Friday, day shift only
Test run Monday-Friday at the State Laboratory.
Collection Instructions Patient's physician must discuss the case and receive approval for submission of specimens from the SF Department of Public Health Communicable Disease Control Unit (415) 554-2830, 24 hours/day, 7 days/wk. The patient's physician will then be contacted by the State Communicable Disease Control Duty Officer of the Day for approval PRIOR to submission of specimens.

Pre-Antitoxin blood: Collect 30 mL blood (Gold top vacutainers x 6), label with patient name, MR#, time & date of collection and "Pre-antitoxin"

Additional samples: To be collected ONLY when recommended by the public health epidemiologist.
(a) 25 gm feces unpreserved or 25 ml of a sterile water enema. Transport immediately to lab or refrigerate.
(b) 25 ml gastric aspirate, if taken within 72 hours of symptom onset. Transport immediately to lab or refrigerate.

Label all samples with patient name, MR# and date and time of collection.

An SFPH laboratory request form must be printed out, completed and sent with a Microbiology requisition and sample to lab Click here for form
Container type Gold top
Amount to Collect 30 mL blood
Sample type Serum (see Collection instructions)
Preferred volume 15 mL serum
UCSF Rejection Criteria No prior approval from Public health authorities. Inadequate or improperly collected sample(s). Name and/or date of collection not on label
Processing notes Samples will normally be processed by Microbiology.

If samples are received after Micro hours, processing should spin the blood, aliquot serum and refrigerate. Stool/enema samples should be refrigerated.

Transport all samples at 4-10C (do not allow cold packs to touch samples) to China Basin Microbiology for referral to San Francisco Public Health Laboratory, 101 Grove St, Rm 412, SF, CA 94102 (415) 554-2800 for arrival Monday through Friday 8 am through 4 pm.
Normal range Negative
Synonyms Botulism immune globulin; BIG
Turn around times 2-4 days typically but may take up to 2 weeks
Additional information Positive results are reported by the Communicable Disease Control Unit to the physician who ordered the test. The patient's physician is required by law to report suspected botulism to the local health department (SF: 554-2800) so that control measures can be formulated.

To learn more about Botulism Click here
LOINC code 29257-3
Last Updated 10/4/2013 10:01:29 PM
Entry Number 141
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