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Voriconazole
| Item | Value | ||||||
|---|---|---|---|---|---|---|---|
| Approval req'd? | No | ||||||
| Available Stat? | No | ||||||
| Test code | VORIC | ||||||
| Performed by | Focus via Quest | ||||||
| Sendout? | Yes | ||||||
| Method | HPLC | ||||||
| Collection Instructions | Collect trough levels just before next dose. Peak levels:
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| Container type | Red top, CSF tube (Gold top unacceptable) | ||||||
| Amount to Collect |
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| Sample type | Serum, CSF | ||||||
| Preferred volume | 2 mL serum or CSF | ||||||
| Min. Volume | 1 mL serum or CSF | ||||||
| UCSF Rejection Criteria | Collected in Gold top. | ||||||
| Processing notes | Centrifuge blood and separate serum from cells as soon as possible. Freeze serum or CSF. Ship frozen to Quest, order test # 19574X | ||||||
| Ref Lab Rejection Criteria | Received thawed. | ||||||
| Units | µg/mL (mcg/mL) | ||||||
| Normal range | Achievable steady state levels with typical dosing range from 2-6 µg/mL. | ||||||
| Stability | Frozen 2 weeks | ||||||
| Turn around times | 5-6 days | ||||||
| Additional information | Voriconazole is a new second-generation triazole antifungal agent. It has been shown to have 10-500 times more potent activity against a broad spectrum of clinically significant fungal pathogens in immunocompromised patients, including fluconazole-resistant Candida and Aspergillus species, as well as emerging fungal pathogens, such as Scedosporium and Fusarium species, which may be resistant to itraconazole, fluconazole, and amphotericin B. Voriconzaole is predominantly metabolized in the liver by the cytochrome P450 enzyme system, mainly by the isozyme CYP2C19. Because of a genetic disposition towards a greater metabolism of the drug by certain population groups, a less effective metabolism by those with hepatic impairment, and because co-administration of other drugs may function to increase or decrease the systemic concentration of voriconazole, it may be clinically helpful to assay the serum/plasma level of voriconazole. |
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| CPT coding | 80299-90 | ||||||
| Last Updated | 5/22/2013 1:16:37 PM | ||||||
| Entry Number | 1378 |
If you have additional questions regarding this test, please call: 415-353-1667