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Chronic Lymphocytic Leukemia, IgVH Mutation Status

Item Value
Approval req'd? No
Available Stat? No
Test code IGVHM
Performed by Quest
Sendout? Yes
Method PCR, gene sequencing
Container type
Blood Lavender top (preferred), Dark green top or Yellow (ACD) top acceptable
Bone marrow Dark green top or Yellow (ACD) top
Amount to Collect
Blood 6 mL
Bone marrow 3 mL
Sample type Whole blood, bone marrow
Preferred volume
Blood 6 mL
Bone marrow 3 mL
Min. Volume Blood 4 mL
Bone marrow 3 mL
UCSF Rejection Criteria Clotted sample
Processing notes Do NOT centrifuge samples. Sore and ship refrigerated.

Order Quest test # 15480X
Ref Lab Rejection Criteria Clotted or frozen sample
Normal range
Synonyms B cell heavy chain mutation; Ig heavy chain mutation
Stability Refrigerated 3 days
Turn around times Test performed once per week. Turnaround time 3-10 days.
Additional information Provides prognostic information for patients who have B-cell chronic lymphocytic leukemia. Patients with mutated IgH variable gene region required minimal or no chemotherapy and had prolonged survival. Patients with unmutated IgH variable gene region responded poorly to continuous multi-regimen chemotherapy and shorter survival. The delineation of mutation status is based on the degree of homology to the germline sequence. A 97% homology cut-off was found to provide a good discrimination.
CPT coding 83891-90, 83894-90, 83900-90, 83901-90 x4, 83902-90, 83904-90, 83909-90, 83912-90
Last Updated 2/25/2014 4:14:45 PM
Entry Number 1365
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