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Pneumococcal IgG Antibodies (23 serotypes)
| Item | Value |
|---|---|
| Approval req'd? | No |
| Available Stat? | No |
| Test code | APN23 |
| Test group | Pneumococcal |
| Performed by | Quest |
| Sendout? | Yes |
| Method | Multiple Analyte Immuno Detection (MAID) |
| Collection Instructions | Pneumococcal vaccine response testing should be performed with paired pre- and post-vaccination sera. Please indicate on request form if the specimen is pre- or post-vaccination collections. Label samples "PRE" or "POST". |
| Container type | Gold top, Red top |
| Amount to Collect | 2 mL blood |
| Sample type | Serum |
| Preferred volume | 1 mL |
| Min. Volume | 0.5 mL |
| Processing notes | Freeze aliquot at -20C. Order Quest Test #16963 |
| Units | µg/mL (mcg/mL) |
| Normal range | See additional information |
| Synonyms | Pneumococcal serology |
| Stability | Room temperature 1 week, refrigerated 2 months, frozen at -20C 1 month. |
| Turn around times | Performed Monday-Friday. Turnaround 4-7 days. |
| Additional information | Serotypes tested for include: 1,2,3,4,5,8,9 (9N),12(12F),14,17 (17F),19(19F),20,22 (22F),23(23F),26(6B),34(10A),43(11A),51(7F),54 (15B),56(18C),57(19A),68(9V),70 (33F) Note: Serotype designations are American nomenclature, with Danish nonemclature in parentheses The MAID procedure measures IgG antibodies recognizing 23 type-specific pneumococcal polysaccharide antigens included in the polyvalent vaccine. Evaluation of the response to pneumococcal vaccination is best accomplished by comparing pre-vaccination antibody levels and levels obtained 4-6 weeks post-vaccination. A 2- to 4-fold increase in type-specific antibodies measured 4-6 weeks after vaccination is expected in immunocompetent adults. The number of serotypes for which a 2- to 4-fold increase is observed varies greatly among individuals; a consensus panel has suggested that individuals older than 5 years should respond to at least approximately 70% of pneumococcal serotypes. Adults >65 years old may exhibit a smaller (2-fold) increase in type-specific antibody levels. |
| CPT coding | 86317-90 x23 |
| Last Updated | 4/3/2012 9:39:13 PM |
| Entry Number | 1333 |
If you have additional questions regarding this test, please call: 415-353-1667