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Pneumococcal IgG Antibodies (23 serotypes)

Item Value
Approval req'd? No
Available Stat? No
Test code APN23
Test group Pneumococcal
Performed by Quest
Sendout? Yes
Method Multiple Analyte Immuno Detection (MAID)
Collection Instructions Pneumococcal vaccine response testing should be performed with paired pre- and post-vaccination sera. Please indicate on request form if the specimen is pre- or post-vaccination collections. Label samples "PRE" or "POST".
Container type Gold top, Red top
Amount to Collect 2 mL blood
Sample type Serum
Preferred volume 1 mL
Min. Volume 0.5 mL
Processing notes Freeze aliquot at -20C. Order Quest Test #16963
Units µg/mL (mcg/mL)
Normal range See additional information
Synonyms Pneumococcal serology
Stability Room temperature 1 week, refrigerated 2 months, frozen at -20C 1 month.
Turn around times Performed Monday-Friday. Turnaround 4-7 days.
Additional information Serotypes tested for include: 1,2,3,4,5,8,9 (9N),12(12F),14,17 (17F),19(19F),20,22 (22F),23(23F),26(6B),34(10A),43(11A),51(7F),54 (15B),56(18C),57(19A),68(9V),70 (33F)

Note: Serotype designations are American nomenclature, with Danish nonemclature in parentheses

The MAID procedure measures IgG antibodies recognizing 23 type-specific pneumococcal polysaccharide antigens included in the polyvalent vaccine.

Evaluation of the response to pneumococcal vaccination is best accomplished by comparing pre-vaccination antibody levels and levels obtained 4-6 weeks post-vaccination. A 2- to 4-fold increase in type-specific antibodies measured 4-6 weeks after vaccination is expected in immunocompetent adults. The number of serotypes for which a 2- to 4-fold increase is observed varies greatly among individuals; a consensus panel has suggested that individuals older than 5 years should respond to at least approximately 70% of pneumococcal serotypes. Adults >65 years old may exhibit a smaller (2-fold) increase in type-specific antibody levels.
CPT coding 86317-90 x23
Last Updated 4/3/2012 9:39:13 PM
Entry Number 1333
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