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|Test Update Information||Effective July 22, 2013, everolimus testing will be performed in-house at Parnassus Chemistry using an immunoassay method. The therapeutic range and potentially toxic concentration remain the same.|
|Performed by||Parnassus Chemistry|
|In House Availability||Monday, Wednesday, Friday day shift only (excluding holidays)|
|Method||Quantitative microsphere system (QMS¨) homogeneous particle-enhanced turbidimetric competitive immunoassay (Thermo Scientific) run on the Beckman DxC 800 instruments|
|Collection Instructions||Trough levels should be collected just before next dose.
NOTE:If patient is taking everolimus AND sirolimus, this immunoassay should not be run to determine the everolimus concentration of the sample. The clinicians should order a MOLT with "ARUP everolimus
|Container type||Lavender top|
|Amount to Collect||3 mL blood|
|Sample type||EDTA whole blood|
|Preferred volume||3 mL blood|
|Min. Volume||1 mL blood|
|UCSF Rejection Criteria||Non-EDTA whole blood samples, clotted samples. samples > 24 hrs old|
|Processing notes||Refrigerate sample.
NOTE: If MOLT order for "ARUP everolimus mass spec assay" is received. Please order ARUP test #0092118 (everolimus by LC-MS/MS). Ship refrigerated.
Note: this therapeutic range is based upon use of everolimus in adult patients to prevent rejection after receiving a kidney transplant. The therapeutic range for the use of everolimus in other indications has not yet been established and may vary from the range documented here.
Kovarik JM et al, Transplantation 2002; 73(6):920-925.
Kovarik JM et al, Therapeutic Drug Monitoring 2004; 26(5):499-505.
McMillin GA et al, Therapeutic Drug Monitoring 2012; 34:222-226.
|Synonyms||Afinitor; Certican; Zortress|
|Stability||Refrigerated 3 days, frozen 28 days.|
|Turn around times||For samples received by 1300 (Monday, Wednesday and Friday) the results will be available the same day.|
|Additional information||This everolimus immunoassay has SIGNIFICANT cross-reactivity with sirolimus. If a patient is on both everolimus and sirolimus, DO NOT order this everolimus immunoassay. Please order a "miscellaneous outside lab test" and write "ARUP everolimus mass spec assay" in the notes section
NOTE:If patient is taking everolimus AND sirolimus, this immunoassay should not be run to determine the everolimus concentration of the sample. The clinicians should order a MOLT with "ARUP everolimus mass spec assay" written in the notes section. Please order ARUP test #0092118 (everolimus by LC-MS/MS). Ship refrigerated.
|Last Updated||9/3/2013 3:30:12 PM|