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Metanephrines, Free, fractionated, plasma

Item Value
Approval req'd? No
Available Stat? No
Test code METNF
Test group Metanephrines
Performed by Quest
Sendout? Yes
Method LC/MS/MS
Patient Preparation Patient should be relaxed in either a supine or upright position before blood is drawn. Patients should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. Overnight fasting is preferred.
Collection Instructions Draw specimen in a pre-chilled EDTA Lavender top (6 mL) and send to Lab on ICE.
Container type Lavender top 6 mL (on ice)
Amount to Collect 6 mL blood
Sample type Plasma
Preferred volume 2.5 mL plasma
Min. Volume 1.5 mL plasma
Processing notes Maintain on ice until centrifuged. Separate the plasma within 2 hours of venipuncture. Freeze plasma immediately. Store frozen at -20C. Ship on dry ice to China Basin. Order Quest test # 19548.
Units pg/mL
Normal range
Metanephrine ≤ 57 pg/mL
Normetanephrine ≤ 148 pg/mL
Total ≤ 205 pg/mL
Synonyms Metanephrines, plasma; plasma metanephrines;
Stability Room temperature 4 hours, refrigerated 2 weeks, frozen at -20C 2 weeks.
Additional information Normetanephrine (NM) and metanephrine (MN) are the extra-neuronal catechol-o-methyltransferase (COMT) metabolites of the catecholamines norepinephrine and epinephrine, respectively. Measurement of plasma metanephrines is more sensitive (but may be less specific) than measurement of catecholamines for the detection of pheochromocytoma. Proper interpretation of results requires awareness of recent medication/drug history(e.f., antihypertensive agents, alcohol, cocaine) and other pre-analytical factors (e.f., stree, severe congestive heart failure, myocardial infarction) that influence release of catecholamines and metanephrines.
CPT coding 83835-90
Last Updated 12/19/2012 4:35:49 PM
Entry Number 1311
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