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If you have additional questions regarding this test, please call: 415-353-1667
Array CGH, prenatal
|Approval req'd?||Yes, if not ordered by Genetics or Neurology faculty or fellows. Requests on inpatients require approval from Cytogenetics/Array staff.|
|Utilization Guidelines||Tests with long turn-around times (ie. Molecular based tests and Microarrays) should only be requested on an inpatient if the result is going to affect the inpatient management.
If the patient will likely be discharged before the result will be available, the test should be requested after discharge. (NOTE: UCSF Medical Center is not reimbursed for inpatient testing).
An exception to the above may be appropriate if there is a possibility the patient will not survive to be discharged and the information is important for diagnosis and/or family decisions/management (ie. recurrence risk).
|Collection Instructions||Insurance pre-authorization required for outpatients
Only collect samples Monday - Friday and avoid holidays.
Transport sample at room temperature as soon as possible to lab. If transport is delayed refrigerate sample.
Print out, complete and submit a Combimatrix requisition with the sample
Click here for form and submit along with a completed UCSF Cytogenetic or Molecular Genetic requisition
There are also instructions available for completing the Combimatrix form. Click here for instructions
|Container type||See sample type|
|Sample type||DNA, POC, Chorionic villi, Amniotic fluid|
|Synonyms||Microarray; Oligo HDscan; aCGH; Oligoarray|
Genomic aberrations that cannot be detected by array CGH assay include:
1. Balanced rearrangement (i.e. balanced translocation, balanced insertion/deletion or inversion)
2. Low level mosaicism
3. Nucleotide sequence changes (i.e. point mutation or small insertion/deletion below the level of detection – per established guidelines <200kb for duplication and deletion)
4. Epigenetic events (i.e. uni-parental disomy, imprinting mutation)
5. Imbalances of regions not represented on the microarray
6. Ploidy change without additional aberration (i.e. 69,XXX)
|Last Updated||2/24/2015 1:25:32 PM|