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Protein, Total, random urine
|Test group||Total protein|
|Performed by||Parnassus, Mission Bay & Mt. Zion Chemistry|
|In House Availability||Test available 24 hours per day 7 days per week|
|Method||Spectrophotometric (pyrogallol red)|
|Container type||Urine cup|
|Amount to Collect||20 mL urine|
|Sample type||Random urine|
|Preferred volume||2 mL urine|
|Min. Volume||1 mL urine|
|Processing notes||Order both TPCUR and CRUR on the sample.|
|Units||mg/dL, mg/mg creatinine|
|Normal range||< 0.16 mg/mg creatinine|
|Stability||Refrigerated 2 days|
|Turn around times||4-14 hours|
|Additional information|| A creatinine is performed on the same sample to calculate the protein/creatinine ratio and will be reported and billed.
In adults, a urine protein/Cr ratio > 0.16 suggests increased proteinuria and a ratio > 3.0 suggests nephrotic range proteinuria (these suggested cutoffs are based on Lane C et al., Nephrology 2006; 11, 245–249, Price C, et all, Clinical Chemistry 2005; 51:1577–1586, and consultation with UCSF Nephrology). In children, a ratio of ≥0.1 has been proposed for proteinuria and > 1.0 for nephrotic range proteinuria (Abitbol C, et al., J Pediatrics 1990; 116:243-247), however, other references indicate that results can vary greatly according to sex and body size and that a single cutoff may not be appropriate for pediatric age groups (Mori Y et al., Pediatr Nephrol 2006; 21: 683–687).
Total urine protein is determined by the pyrogallol red method using a human albumin standard. This method is effective in detecting albumin and non- albumin proteins, including immunoglobulins. 24 hour urine protein excretion may be increased in a variety of conditions including renal disease, Bence Jones proteinuria, amyloidosis, hemorrhage, systemic infections, heart failure, dehydration, starvation, strenuous exercise, pregnancy, sickle cell disease, exposure to extreme cold and psychological stress.
Comparison of measured urine protein reading to dipstick 'scale' reading:
|Last Updated||6/21/2016 12:11:45|
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