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UroVysion (TM) FISH
|Test group||Oncology FISH|
|In House Availability||Run 1x per week, Wednesday, day shift only|
|Method||Fluorescent in-site hybridization (FISH)|
|Patient Preparation||Clean-catch, voided urine is preferred. First morning collection increases cell yield. Other means of collection (e. g., bladder wash) are acceptable|
|Collection Instructions||Urine should be mixed 2:1 with preservative (Carbowax) immediately after collection|
|Container type||50 mL conical tube prefilled with Carbowax, available at the Mount Zion Urology practice and UCSF Mount Zion Clinical Laboratory.|
|Sample type||Random urine (first AM void preferred) or bladder wash|
|Preferred volume||50 mL|
|Min. Volume||30 mL|
|UCSF Rejection Criteria||Specimen not collected in preservative, too old or < 30 mL|
|Processing notes||Forward urine collected in Carbowax preservative to China Basin Processing.|
|Units||Numbers of cells with extra copies of chromosomes 3, 7 and 17. Number of cells with loss of both copies of 9p21|
|Normal range||≤ 3 cells showing gains for 2 or more chromosomes (3, 7 or 17) in the same cell and ≤ 11 cells showing zero 9p21 signals.|
|Synonyms||bladder cancer;urothelial carcinoma|
|Stability||Room temperature 24 hours, refrigerated with preservative 1 week.|
|Turn around times||10-14 days|
|Additional information||An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.
UroVysionTM FISH is an FDA approved test for the detection of numerical chromosomal abnormalities associated with recurrent urothelial carcinoma.
Minor modifications to the procedure were validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
|LDT or Mod FDA?||Yes|
|Last Updated||6/22/2015 10:22:28 AM|