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Lab Manual for Moffitt-Long and Mount Zion

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UroVysion (TM) FISH

Item Value
Approval req'd? No
Available Stat? No
Test code UROV
Test group Oncology FISH
Performed by Medical Genomics - Molecular Diagnostics
In House Availability Run 1x per week, Wednesday, day shift only
Method Fluorescent in-site hybridization (FISH)
Patient Preparation Clean-catch, voided urine is preferred. First morning collection increases cell yield. Other means of collection (e. g., bladder wash) are acceptable
Collection Instructions Urine should be mixed 2:1 with preservative (Carbowax) immediately after collection
Container type 50 mL conical tube prefilled with Carbowax, available at the Mount Zion Urology practice and UCSF Mount Zion Clinical Laboratory.
Sample type Random urine (first AM void preferred) or bladder wash
Preferred volume 50 mL
Min. Volume 30 mL
UCSF Rejection Criteria Specimen not collected in preservative, too old or < 30 mL
Processing notes Forward urine collected in Carbowax preservative to China Basin Processing.
Units Numbers of cells with extra copies of chromosomes 3, 7 and 17. Number of cells with loss of both copies of 9p21
Normal range ≤ 3 cells showing gains for 2 or more chromosomes (3, 7 or 17) in the same cell and ≤ 11 cells showing zero 9p21 signals.
Synonyms bladder cancer;urothelial carcinoma
Stability Room temperature 24 hours, refrigerated with preservative 1 week.
Turn around times 10-14 days
Additional information An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.

UroVysionTM FISH is an FDA approved test for the detection of numerical chromosomal abnormalities associated with recurrent urothelial carcinoma.

Minor modifications to the procedure were validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
CPT coding 88120
LDT or Mod FDA? Yes
Last Updated 1/22/2014 8:59:52 AM
Entry Number 1123

If you have additional questions regarding this test, please call: 415-353-1667

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