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1p and 19q deletion FISH

Item Value
Approval req'd? Only performed on samples submitted by UCSF Neuropathology
Available Stat? No
Test code
Test group Oncology FISH
Performed by Medical Genomics - Molecular Diagnostics
In House Availability Run 2x per week, Monday & Wednesday, day shift only
Method Fluorescent in-situ hybridization (FISH)
Collection Instructions For UCSF Samples (from remote sites) Click here for sample collection instructions

For NON-UCSF Samples Click here for Requisition form & Account set-up instructions. Note we only do institutional billing.
Container type
Sample type Formalin-fixed, paraffin-embedded tissue on six (6) unstained slides (5 microns thick) on charged glass. One adjacent hematoxylin and eosin stained (H&E) slide should also be included. Slides should be labeled with pathology case number and block identification..
UCSF Rejection Criteria All required slides not included. Insufficient tumor present on slide as determined by pathologist. Slides not labeled or not accompanied by completed requisition form.
Units Ratio of 1p:1q signals
Ratio of 19q:19p signals
Normal range Ratio > 0.8 (no deletion)
Synonyms 1p/19q deletion; oligodendroglioma
Stability Slides are stable indefinitely at room temperature
Turn around times 10-14 days
Additional information An interpretation of this test by a laboratory physician will automatically be performed and billed for separately.

1p and 19q deletion by FISH is designed to detect loss of chromosome loci 1p and 19q, which has been seen in oligodendroglial tumors and which has been associated with improved prognosis and response to therapy in patients with primary brain tumors.

The clinical interpretation of this test should be evaluated within the context of the patient's medical history, other diagnostic tests, and the histologic and immunohistochemical features of the tumor.

The test was validated by UCSF Clinical Laboratories to confirm performance characteristics, in compliance with current guidelines for clinical implementation.
CPT coding 88368 x4
LDT or Mod FDA? Yes
Last Updated 1/22/2014 8:59:52 AM
Entry Number 1122
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