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Topiramate

Item Value
Approval req'd? No
Available Stat? No
Test code TOPA
Performed by Quest
Sendout? Yes
Method Flourescent polarization immunoassay
Collection Instructions Draw peak 2-4 hours after dose, trough 0.5-1 hour before dose when patient is at steady state. Avoid hemolysis
Container type Red top preferred, Dark green top acceptable (Gold top NOT acceptable)
Amount to Collect 2 mL blood
Sample type Serum (plasma acceptable)
Preferred volume 1 mL serum or plasma
Min. Volume 0.5 mL serum or plasma
UCSF Rejection Criteria Drawn in Gold top or Light green top vacutainer. Hemolysis, Lipemia
Processing notes Maintain sample at room temperature. Order Quest # 30965
Units µg/mL (mcg/mL)
Normal range
Daily dose (mg) Peak Trough
100 6.5-9.2 µg/mL 4.5-6.6 µg/mL
200 12-16 µg/mL 8-12 µg/mL
400 20-30 µg/mL 14-20 µg/mL
Synonyms Topamax
Stability Room temperature 1 week, refrigerated 2 weeks, frozen at -20C 1 month
Turn around times Performed 5x per week. Turnaround 4-8 days
Additional information Topiramate is an antidepressant used as an adjunctive treatment of partial epilepsy and Lennox-Gastaut syndrome in children. Monitoring is useful to optimize dose and avoid toxicity.
CPT coding 80201-90
LOINC code 17713-9
Last Updated 10/28/2013 11:49:06 AM
Entry Number 1108
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