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Lab Manual for Moffitt-Long and Mount Zion

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Plasminogen Activator Inhibitor - 1 antigen

Item Value
Approval req'd? No
Available Stat? No
Test code PAI1AG
Test group Plasminogen
Performed by Quest
Sendout? Yes
Method Enzyme immunoassay
Collection Instructions 1. Check the expiration date on the label of the blue top vacutainer before drawing the patient.

2. For blood collection in a sodium citrate blue top, the tube must be filled to above the Minimum Fill Indicator on the tube. It is crucial to wait and allow the tube to stop filling before removing it from the needle.

3. With use of a butterfly needle, draw about 1 cc using a separate blue top to remove air from tubing, discard the first tube and then draw a second blue top tube filled to the full extent of the vacuum.

4. Tubes should not be filled past the Maximum Fill dashed line by either using a syringe or removing the tube cap.

The venipuncture must be clean, with no trauma. The first 5 mL of blood drawn from a patient should not be used for coagulation testing. If drawn through an indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected before collecting the specimen for coagulation testing.

Blood should not be collected from heparinized lines.
Container type Blue top filled to full extent of vacuum
Amount to Collect 2.7 mL blood
Sample type Citrated Plasma
Preferred volume 1 mL plasma
Min. Volume 0.5 mL plasma
UCSF Rejection Criteria Samples collected in outdated blue top vacutainer. Over-filled or under-filled tubes may be rejected
Processing notes Forward blue top to Hematology for processing. Aliquot separated plasma into 1 mL sample and freeze in plastic tubes at -20C. Platelet contamination of a test sample will tend to falsely elevate results. Ship on dry ice to China Basin sendout M-F for processing to Quest or LabCorp Ref. Labs. Order Quest test # 59766P, if B/T patient order BTMOLT, order LabCorp test # 500057.
Ref Lab Rejection Criteria Sample received thawed.
Units ng/mL
Normal range 4-43 ng/mL
Synonyms PAI-1 antigen
Stability Room temperature 8 hours, refrigerated 3 days, frozen at -20C 6 months.
Turn around times Set up Wednesday and Friday; Report available: 3 days
Additional information Deep vein thrombosis and coronary artery disease have been variably associated with increased PAI-1 levels. Elevated PAI-1 levels my help predict risk of reinfarction in survivors of myocardial infarction, particularly in young individuals.

Deficiency of PAI-1, a rare condition that is difficult to diagnose, has been associated with a bleeding diathesis.

As an acute phase reactant, the activity is increased after an acute event. Elevated levels may also be seen in diabetes and pregnancy.

Studies suggest PAI-1 may be prognostic marker in early stage breast cancer.
CPT coding 85414-90
LOINC code 22758-7
Last Updated 12/16/2013 10:29:04 AM
Entry Number 1107

If you have additional questions regarding this test, please call: 415-353-1667

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