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Beta-2-glycoprotein Antibody, IgG
|Clinical Questions||Does my patient have antiphospholipid syndrome (APLS)?|
|In House Availability||Tuesday (day shift)|
|Container type||Gold top preferred, Red top acceptable|
|Amount to Collect||3 mL blood|
|Preferred volume||1 mL serum|
|Min. Volume||0.5 mL serum|
|UCSF Rejection Criteria||Lipemia or gross hemolysis.|
|Processing notes||If Beta-2-Glycoprotein Antibodies are ordered without further specification, order both Beta -2-Glycoprotein Antibodies IgG and IgM (B2GPG and B2GPM).
Freeze serum at -20C.
|Units||SGU (Standard IgG B2 GPI Units)|
|Normal range||< 21 SGU|
|Turn around times||Turn around time 2-8 days|
|Additional information||If Beta-2-Glycoprotein Antibodies are ordered without further specification, only Beta -2-Glycoprotein Antibodies IgG and IgM (B2GG and B2GM) will be done.
Antiphospholipid antibodies (APA) are associated with an increased risk of venous and arterial thrombosis and recurrent fetal loss.These antibodies can be IgG, IgM, or IgA.
Antiphospholipid antibodies require several different tests for detection. Lupus anticoagulants are detected by clotting methods. APA such as anticardiolipin antibody and anti-beta 2 glycoprotein 1 antibodies are detected by immunologic assays. Anti-Beta 2 Glycoprotein Antibodies are a more specific marker for increased risk of thrombosis than anticardiolipin assays. APA associated with thrombotic risk are persistent, and should be confirmed by a repeat positive test after 2-3 months. APA results aid in diagnosis and are helpful in determining the intensity and duration of anticoagulant treatment for patients with Antiphospholipid Syndrome and thrombosis.
|Last Updated||4/11/2012 8:20:16 PM|