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Lab Manual for Moffitt-Long and Mount Zion

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Beta-2-glycoprotein Antibody, IgA

Item Value
Available Stat? No
Test code B2GA
Test group Beta-2-glycoprotein
Performed by Quest (Labcorp for B&T patients)
Sendout? Yes
Method EIA
Container type Red top
Amount to Collect 3 mL blood
Sample type Serum
Preferred volume 2 mL serum (Note this is sufficent to perform IgA, IgG, and IgM antibody testing)
Min. Volume 1 mL serum
UCSF Rejection Criteria Gross hemolysis or lipemia
Processing notes If Beta-2-Glycoprotein Antibodies are ordered without further specification, order Beta -2-Glycoprotein Antibodies IgG and IgM (B2GPG and B2GPM).

Centrifuge red top tube within 60 minutes of collection. Immediately freeze serum at -20C and ship frozen on dry ice. Order Quest test #36552.

For B&T patients order labCorp test # 1639000 and send serum at room temperature.
Ref Lab Rejection Criteria Received thawed. Gross hemolysis or lipemia
Units SAU
Normal range ≤ 20 SAU
Stability Frozen 1 month.
Turn around times Run Monday and Wednesday mornings. Results available Tuesday or Thursday afternoon.
Additional information If Beta-2-Glycoprotein Antibodies are ordered without further specification, only Beta -2-Glycoprotein Antibodies IgG and IgM (B2GPG and B2GPM) will be done. These two tests are performed in house.

Antiphospholipid antibodies (APA) are associated with an increased risk of venous and arterial thrombosis and recurrent fetal loss.These antibodies can be IgG, IgM, or IgA.

Antiphospholipid antibodies require several different tests for detection. Lupus anticoagulants are detected by clotting methods. APA such as anticardiolipin antibody and anti-beta 2 glycoprotein 1 antibodies are detected by immunologic assays. Anti-Beta 2 Glycoprotein Antibodies are a more specific marker for increased risk of thrombosis than anticardiolipin assays. APA associated with thrombotic risk are persistent, and should be confirmed by a repeat positive test after 2-3 months. APA results aid in diagnosis and are helpful in determining the intensity and duration of anticoagulant treatment for patients with Antiphospholipid Syndrome and thrombosis. The clinical significance of IgA Beta-2-glycoprotein antibodies is not definitively established.
CPT coding 86146-90
LOINC code 21108-6
Last Updated 3/7/2011 2:13:06 PM
Entry Number 1043

If you have additional questions regarding this test, please call: 415-353-1667

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