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Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

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Additional Details

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Item Value
ClinicalQuestion Does my patient have antiphospholipid syndrome (APLS)?
TestEntryNumber 802
TestCode PTT
TestName Complete Blood Count (includes Platelet Count)
Synonyms blood count; CBC; hematology survey; RBC; Red cell count; Hemoglobin; Hematocrit; Red Cell Indices
IsThisScreeningTest No
PubMedID 18755986, 16420554, 12393574, 22951216
Comment Approximately 50% of patients with anti-phospholipid syndrome will have a normal PTT. Therefore, the PTT is not useful in evaluating for antiphospholipid syndrome. The anti-phopholipid antibody panel should be ordered instead. It includes assays for anti-cardiolipin and anti-beta2-glycoprotein (IgG and IgM) and two tests for lupus anticoagulants (Russel's viper venom and a PTT-based hexogonal phospholipid neutralization). The presence of clinical criteria and at least one positive laboratory criteria (with repeat positivity at least 12 weeks apart) establishes a diagnosis of anti-phospholipid syndrome. Laboratory testing must be done at least 12 weeks after a qualifying event.
Sensitivity 50%
Specificity Unknown
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