UCSF Navigation Bar

UCSF Departments of Pathology & Laboratory Medicine Home Page

Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

Internal Resources

Clinical Question: Does my patient have syphilis?

Item Value
ID 6
Question Does my patient have syphilis?
AlgorithmLink Click here for algorithm
AlgorithmDescription UCSF currently recommends a basic two-stage approach for syphilis testing, designed to maximize positive predictive value: screening with a non-treponemal method (RPR for serum or VDRL for CSF), followed by a confirmatory treponemal test (TP-PA). Clinical correlation is recommended for all test results, with possible causes of negative test results provided in the algorithm.
ICD10 A51.0, A51.3, A51.5, A52.1, A52.8
PubMedID 13129993, 13129993, 21346050, 18080352, 17062183, 7826278

Kennedy, Jr EJ and Creighton ET. Venereal Disease Research Laboratory (VDRL) Slide Tests. Chapter 8, pp 159-178. In: Larsen SA, Pope, V., Johnson, R.E., and Kennedy, Jr., E.J., Eds. A Manual of Tests for Syphilis, 9th Ed. Amer. Public Health Assoc. Washington, DC, 1998. (no Pubmed ID)

U.S. Preventive Services Task Force. Screening for Syphilis Infection: Recommendation Statement. July 2004. http://www.uspreventiveservicestaskforce.org/3rduspstf/syphilis/syphilrs.htm (no Pubmed ID)


Tests associated with this clinical question:

Click on the test name for more information about the use of this test to answer this clinical question

ID Test Code Test Name Comment
28 RPRN, RPRNO, RPR, RPRO Rapid Plasma Reagin Not Specified
29 VDRL VDRL, CSF Not Specified
30 TPAB Treponemal Antibody Not Specified
31 FTAC FTA-ABS Can be performed on those suspected on having neurosyphilis, as a confirmatory test, after VDRL is performed.


Clinical Algorithm:

It appears that you do not have a PDF plugin for this browser. You can Click Here to download the PDF file.

UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center