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Clinical Question: Does my patient have thalassemia?

Item Value
ID 2
Question Does my patient have thalassemia?
AlgorithmLink Click here for algorithm
AlgorithmDescription Thalassemia testing may be considered in at-risk patients with microcytosis. A peripheral blood smear can be evaluated for RBC morphologic changes. Iron studies are helpful to distinguish between thalassemia and anemia of other etiologies. HPLC/hemoglobin electrophoresis are used to confirm the diagnosis of thalassemia and/or hemoglobinopathy. Genetic testing may be considered if clinically indicated. This algorithm is not sufficient for prenatal planning purposes.
ICD10 D56.0, D56.1, D56.3, D56.8, D56.9


Tests associated with this clinical question:

Click on the test name for more information about the use of this test to answer this clinical question

ID Test Code Test Name Comment
7 CBC Factor 8 Activity No. However, there is a higher prevalence of thalassemia in populations from Africa, Middle East, Mediterranean, South American, Caribbean and Asia.
8 FERR Hemochromatosis, Hereditary
9 HBEP Hemoglobinopathy Evaluation
10 BTHL Alpha Thalassemia mutations
11 ATHL Beta Thalassemia mutations (incl. HbS, HbC, HbE)


Clinical Algorithm:

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