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Clinical Question: Does my patient have histoplasmosis?

Item Value
ID 13
Question Does my patient have histoplasmosis?
AlgorithmLink Click here for algorithm
AlgorithmDescription Urine and serum antigen testing is first-line for diagnosis of H. capsulatum infection. Serological testing can also be informative in patients who are not immunosuppressed. Bone marrow is the preferred specimen for culture. Tissue biopsy is also high yield for diagnosis if obtained from involved site.
ICD10 B39
PubMedID 21810734


Tests associated with this clinical question:

Click on the test name for more information about the use of this test to answer this clinical question

ID Test Code Test Name Comment
65 HISTAG Fungal Culture, Blood This test is useful in any patient suspected of disseminated H. capsulatum infection. Urine antigen test is first line test.
66 HSTO Fungal Culture, other fungi Most useful in patients who are not immunosuppressed.
67 HICFB Histoplasma capsulatum Antibody Immunodiffusion More sensitive than serological testing for H. capsulatum by immunodiffusion (HSTO). Can be used to follow titers.
68 P258 Histoplasma capsulatum Antibody, by Complement Fixation Not Specified
69 P256 Histoplasma capsulatum Antigen Bone marrow is the preferred specimen for culturing H. capsulatum.


Clinical Algorithm:

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