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Clinical Question: Does my patient have histoplasmosis?

Item Value
ID 13
Question Does my patient have histoplasmosis?
AlgorithmLink Click here for algorithm
AlgorithmDescription Urine and serum antigen testing is first-line for diagnosis of H. capsulatum infection. Serological testing can also be informative in patients who are not immunosuppresssed. Bone marrow is the preferred specimen for culture. Tissue biopsy is also high yield for diagnosis if a distinct lesion is present.
ICD10 B39
PubMedID 21810734

 

Tests associated with this clinical question:

Click on the test name for more information about the use of this test to answer this clinical question

ID Test Code Test Name Comment
65 HISTAG Histoplasma capsulatum Antigen This test is useful in any patient suspected of H. capsulatum infection. Urine antigen test is first line test.
66 HSTO Histoplasma capsulatum Antibody Immunodiffusion Most useful in patients who are not immunosuppressed.
67 HICFB Histoplasma capsulatum Antibody, by Complement Fixation More sensitive than serological testing for H. capsulatum by immunodiffusion (HSTO). Can be used to follow titers.
68 P258 Fungal Culture, Blood Not Specified
69 P256 Fungal Culture, other fungi Bone marrow is the preferred specimen for culturing H. capsulatum.

 

Clinical Algorithm:

algorithm image

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