Clinical Question: Does my patient have drug-induced thrombocytopenia (including HIT)?
|Question||Does my patient have drug-induced thrombocytopenia (including HIT)?|
|AlgorithmLink||Click here for algorithm|
|AlgorithmDescription||"Evaluation of drug induced thrombocytopenia includes: |
1. Review of the 4Ts to assess pretest probability,
2. Perform HPF4 ELISA for all stratification levels. A low 4T score and negative HPF4 could suggest decreased possibility of HIT.
3. Order SRA or other functional platelet assays. "
|PubMedID||12965896,22422328, 20665476, 23606934|
Tests associated with this clinical question:
Click on the test name for more information about the use of this test to answer this clinical question
|ID||Test Code||Test Name||Comment|
|51||HIPAB||Heparin-PF4 Complex Antibodies (Revised Test)||Test should be performed only after reviewing clinical risk factors (4 T's) and before performing a serotonin release assay (SRA).|
|52||SRAU||Serotonin Release Assay||This test must be done after positive HPF4 (platelet factor 4) antibody result.|
|53||AGGR||Platelet Aggregation||Not used often, but applicable when desiring to evaluate platelet function.|
|54||MOLT||Misc. Outside Laboratory Test||Platelet Microparticle Generation assay is a research test. Flow cytometry assay. Good correlation with SRA and clinical outcome.|
|55||PLT, CBC , CBCD, PLTM||Platelet Count||Not Specified|