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Clinical Question: Does my patient have hemophagocytic lymphohistiocytosis?

Item Value
ID 1
Question Does my patient have hemophagocytic lymphohistiocytosis?
AlgorithmLink Click here for algorithm
AlgorithmDescription There are two ways to diagnose HLH currently: fulfillment of 5 of 8 clinical criteria or genetic testing for a characteristic HLH mutation. Most patients can be diagnosed and treated on the basis of clinical criteria, because genetic testing has a long turn around time, is more expensive and the sensitivity can be low.
ICD10 D76.1, D76.2, D76.3
PubMedID 21828139, 12539072, 24407034


Tests associated with this clinical question:

Click on the test name for more information about the use of this test to answer this clinical question

ID Test Code Test Name Comment
1 FERR Hemochromatosis, Hereditary Not Specified
2 CBC Factor 8 Activity Not Specified
3 TRIG Ferritin Not Specified
4 Fibrinogen, Functional Not Specified
5 FIB Miscellaneous Outside Laboratory Test Not Specified
6 MOLT Misc. Outside Laboratory Test Send-out genetic testing for HLH-causing mutations is low sensitivity and therefore many be indicated only if family history is present.


Clinical Algorithm:

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