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2010 Annual UCSF and Stanford Current Issues in Anatomic Pathology

Endometrial Alterations that Mimic Cancer: Navigating Around Common Problems in Biopsies/Curettages


Date, Time, Place

  • June 4, 2010, 10:20 AM - 11:00 AM, Hotel Nikko, San Francisco


A spectrum of metaplastic and hyperplastic changes may affect the endometrium. In biopsies and curettage specimens, the appearance of these benign alterations may mimic neoplasia. This lecture will review common forms of endometrial metaplastic and hyperplastic changes and the criteria that allow distinction from neoplasia, including the role of selected immunohistochemical markers. In addition, this lecture will review the effects of hormonal treatment for atypical hyperplasia or well-differentiated endometrioid adenocarcinoma and will provide a practical guide to evaluation of subsequent surveillance endometrial samples. Finally, the lecture will highlight alterations in endometrial polyps that may mimic neoplasia.

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