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Cellular Therapy: BMT Laboratory Service

Cellular Therapy: BMT Laboratory Service

Contact Information

Director

Supervisor

Staff

  • Lucy Chen, CLS (ASCP)
  • Christine Cheng, BS Genetics – HLT-I
  • Katrina De la Cruz, MLS (ASCP)
  • Melanie McMillan CLS (ASCP)
  • Jennifer Rasmussen CLS (ASCP)
  • Robert Romano, CLS, CIS

Associated Personnel (Adult Hematopoietic Malignancies Program Faculty)

Hours of Operation

  • Monday - Friday 8am-6pm
  • Saturday 8am-4:30pm

Location

  • UCSF Moffitt Hospital
  • 505 Parnassus Avenue, Room M-547
  • San Francisco, CA 94143
  • Phone: 415-353-1789
  • Fax: 415-353-1227

Overview

The UCSF Blood and Marrow Transplant (BMT) Laboratory serves the needs of adult patients cared for by the UCSF hematologic malignancies program, which is part of the UCSF Comprehensive Cancer Center. Since the transplant program's inception in 1986, nearly 2000 adult patients with a wide range of hematologic and some non-hematologic disorders have undergone bone marrow or blood stem cell transplants. The UCSF hematologic malignancies program currently provides hematopoietic stem cell transplants for over 120 adult patients each year. The program offers a wide range of therapeutic options, including UCSF-specific treatment protocols, and protocols that are part of national multi-center networks, including the Cancer and Leukemia research Group B (CALGB) and the Aids Malignancy Consortium (AMC). The program also participates in the National Marrow Donor Program (NMDP) as a Transplant Center and a Collection Center.

The UCSF BMT laboratory processes over 300 blood and marrow stem cell collections each year, including autologous, related allogeneic, unrelated allogeneic, and cord blood units. The laboratory is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT), the American Association of Blood Banks (AABB), the College of American Pathologists (CAP), and the Clinical Laboratories Improvement Amendment (CLIA), and is registered with the State of California Department of Health and the Food and Drug Administration (FDA).

The BMT laboratory processes blood and marrow stem cell collections for immediate use and offers long-term cell storage in liquid nitrogen for patients who will require a future transplant. Some collections are modified in vitro as part of research and clinical practice protocols. All BMT laboratory activities are performed within the Good Manufacturer’s Practice (GMP) and Good Tissue Practice (GTP) guidelines of the state and federal government, and within professional society guidelines.

Cellular Therapy: BMT Laboratory Services
Service Name Moffitt Mt. Zion SFGH VAMC

Blood and Marrow stem cell processing

The BMT Laboratory performs cell processing to support approved clinical protocols and clinical trials. This includes unmodified and modified stem cell protocols for immediate and future use. All BMT laboratory activities are performed within the Good Manufacturer's Practice (GMP) and Good Tissue Practice (GTP) guidelines of the state and federal government, and within professional society guidelines. Processing of samples for patients other than those approved in the weekly adult hematologic malignancies meeting requires approval by Joy Cruz at 415-353-1351.

Yes

Long-term storage

All autologous and some allogeneic stem cell products are collected prior to the date of infusion and require storage in liquid nitrogen for future transplantation. The adult BMT laboratory performs program-rate freezing on units that require cryopreservation. Standard storage is for up to 5 years from the time of collection. For details or to answer questions, call Joy Cruz at 415-353-1351.

Yes

Stem and progenitor cell infusion

The BMT laboratory assists the clinicians with all stem and progenitor cell infusions. Infusions are arranged during the weekly adult blood and marrow transplant conference. Additions and modifications require direct communication with Joy Cruz at 415-353-1351.

Yes

Surface phenotype analysis

The BMT laboratory performs surface CD34 and CD3 expression analysis on stem cell samples as requested by transplant physicians. Contact the BMT lab at 415-353-1789 for details on ordering or accessing results. The immunology laboratory (415-353-1217) within the UCSF Clinical laboratory performs CD34 and CD3 expression analysis on cells other than those used for hematopoietic transplantation.

Yes

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