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Nancy M. Joseph, MD, PhD

Research and Clinical Interests

My clinical and research interests are in the areas of gastrointestinal and molecular pathology with a focus on improving tumor diagnosis and classification by integrating molecular data with histologic features and immunohistochemical data.

Selected Publications

  • Krings G*, Joseph NM*, Bean G, Solomon, D, Onodera C, Talevich E, Yeh I, Grenert JP, Hosfield E, Crawford ED, Jordan RC, Van Zante M, Zaloudek C, Shin S, and Chen YY. Genomic Profiling of Breast Secretory Carcinomas Reveals Distinct Genetics from Other Breast Cancers and Similarity to Mammary Analogue Secretory Carcinomas. Modern Pathol. In press.
  • Bean GR, Joseph NM, Gill RM, Folpe AL, Horvai AE, Umetsu SE. Recurrent GNAQ mutations in anastamosing hemangiomas. Modern Pathol. 2017 May;30(5):722-727. doi: 10.1038/modpathol.2016.234.
  • Joseph NM, Pineda C, and Rabban JT. DNA Genotyping of Non-Molar Donor Egg Pregnancies with Abnormal Villous Morphology: Allele Zygosity Patterns Prevent Misinterpretation as Complete Hydatidiform Mole. Int J Gynecol Pathol. 2017 Apr 29. doi: 10.1097/PGP.0000000000000395. [Epub ahead of print]
  • Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, and Solomon D. Genomic Profiling of Malignant Peritoneal Mesothelioma Reveals Recurrent Alterations in Epigenetic Regulatory Genes BAP1, SETD2, and DDX3X. Modern Pathol. 2016 Nov 4. doi: 10.1038/modpathol.2016.188.
  • Kline CN*, Joseph NM*, Grenert JP, Van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Campomanes A, Banerjee Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn M, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T,†, and Solomon T,† Targeted next-generation sequencing of pediatric brain tumor patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-Oncology. 2016 Nov 14. pii: now254.
  • Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh M, and Ferrell LD. Hepatic Small Vessel Neoplasm, a Rare Infiltrative Vascular Neoplasm of Uncertain Malignant Potential. Human Pathology. 2016 Apr 14. pii: S0046-8177(16)30037-5. doi: 10.1016/j.humpath.2016.03.018.
  • Liu SY, Joseph NM, Ravindranathan A, Stohr B, Greenland N, Vohra P, Hosfield E, Yeh I,Talevich E, Onodera C, Van Ziffle J, Grenert JP, Bastian B, Chen YY, and Krings G. Genomic Profiling of Malignant Phyllodes Tumors Reveals Aberrations in FGFR1 and PI-3 Kinase/RAS Signaling Pathways and Provides Insights into Intratumoral Heterogeneity. Modern Pathology. June 3, 2016. doi: 10.1038/modpathol.2016.97.
  • Joseph NM, Solomon DA, Frizzell N, Rabban JT, Zaloudek, C, and Garg K. Morphology and immunohistochemistry for 2SC and FH aid in detection of fumarate hydratase gene aberrations in uterine leiomyomas from young patients. Am J Surg Pathol. 2015 Nov; 39(11):1529-39.
  • Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, and Kakar, S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology. 27(1): 62-72, 2014.
  • Joseph NM, Phillips J, Dahiya S, Felicella M, Tihan T, Brat DJ, Perry A. Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants. Modern Pathology. 26(3): 315-26, 2013.
  • Joseph NM, He S, Quintana E, Kim Y, Nunez G, and Morrison SJ. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. Journal of Clinical Investigation, 121(9): 3398-411, 2011.
  • Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M, Conway SJ, Parada LF, Zhu Y, and Morrison SJ. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell. 13(2): 129-140, 2008.
Nancy M. Joseph, MD, PhD
  • Associate Professor
  • Pathology
  • Division: Surgical Pathology

Specialty Areas

  • Gastrointestinal and Molecular Pathology

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Nancy M. Joseph, MD, PhD
  • Pathology, Box 0102
  • 513 Parnassus Avenue, Room HSW-450
  • San Francisco, CA 94143

Hospital Affiliation(s)

  • Moffitt-Long
  • Mt. Zion
  • San Francisco General
  • San Francisco VA
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