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Marta Margeta, MD, PhD

Research and Clinical Interests

The long-term goal of our basic research is to elucidate how altered ion channel signaling contributes to the selective vulnerability of different cell populations in the brain and skeletal muscle, thus influencing onset and/or progression of different neurologic disorders. We use a combination of different approaches (molecular and cell biology, immunohistochemistry, biochemistry, electrophysiology, and muscle genetics) to investigate two distinct but related areas: (1) the function of intrinsic antioxidant signaling in the brain and skeletal muscle and (2) the role of autophagy impairment in neurologic disease pathogenesis.

The goal of our translational research is to develop new immunohistochemical tools for tissue-based diagnosis of neurologic disorders.

Selected Publications

  • Habas A., Wang X., Hahn J., and Margeta M. Neuronal activity regulates astrocytic Nrf2 signaling. In revision (2013)
  • Hiniker A., Daniels B.H., Lee H.S., Margeta M. Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies. Acta Neuropathol Commun 1:29 (2013)
  • Daniels B.H., McComb R.D., Mobley B.C., Gultekin S.H., Lee H.S., Margeta M. LC3 and p62 as diagnostic markers of drug-induced autophagic vacuolar cardiomyopathy: A study of three cases. Am J Surg Pathol 37:1014-21 (2013)
  • Lee H.S., Daniels B.H., Salas E., Bollen A.W., Debnath J., and Margeta M. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: A case-control study. PloS ONE 7:e36221 (2012)
  • Chandiramani N, Wang X, and Margeta M. Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line. PLoS ONE 6: e14485 (2011)

Selected Awards

  • 2012 The Haile T. Debas Academy of Medical Educators Excellence in Teaching Award
  • 2007-2012 NIH Mentored Clinical Scientist Development Award
  • 1996 Klaus R. Unna Award, for outstanding research accomplishments as a graduate student
  • 1990 University of Zagreb Chancellor’s Award, for outstanding academic performance as a medical student

Additional Information

Marta Margeta, MD, PhD
  • Assistant Professor, Director of Neuromuscular Pathology Service, Medical Director of Laboratory for Neuromuscular Special Studies
  • Pathology
  • Neuropathology

Specialty Area

Neuroscience Research; Neuromuscular Pathology

Contact Information

  • UCSF Department of Pathology
  • 513 Parnassus Avenue
  • Room HSW-514, Box 0511
  • San Francisco CA 94143-0511

Web Sites

Other UCSF Organizational Association(s)

  • Biomedical Sciences (BMS) Graduate Program

Hospital Affiliation(s)

  • Moffitt-Long
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