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Marta Margeta, MD, PhD

Research and Clinical Interests

The long-term goal of our basic research is to elucidate activation of stress response signaling in the brain and skeletal muscle contributes to neurologic health and disease. Specifically, we use a combination of different experimental approaches (molecular and cell biology, immunohistochemistry, biochemistry, and electrophysiology) in human tissue and animal / cellular models of disease to investigate three distinct but related stress response pathways: (1) the Keap1/Nrf2 antioxidant pathway; (2) autophagy; and (3) astrocyte activation.

The goal of our translational research is to develop new immunohistochemical tools for tissue-based diagnosis of neurologic disorders.

Selected Publications

  • Hahn J., Wang X., and Margeta M. Astrocytes increase the activity of synaptic GluN2B NMDA receptors. Front Cell Neurosci 9:117 (2015)
  • Villalta S.A., Rosenthal W., Martinez L., Sparwasser T., Tidball J.G., Margeta M., Spencer M., Bluestone J.A.: Regulatory T cells suppress muscle inflammation and injury during muscular dystrophy. Science Transl Med 6:258ra142 (2014)
  • Habas A., Hahn J., Wang X., and Margeta M. Neuronal activity regulates astrocytic Nrf2 signaling. Proc Natl Acad Sci USA 45:18291-6 (2013)
  • Hiniker A., Daniels B.H., Lee H.S., Margeta M. Comparative utility of LC3, p62 and TDP-43 immunohistochemistry in differentiation of inclusion body myositis from polymyositis and related inflammatory myopathies. Acta Neuropathol Commun 1:29 (2013)
  • Lee H.S., Daniels B.H., Salas E., Bollen A.W., Debnath J., and Margeta M. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: A case-control study. PloS ONE 7:e36221 (2012)

Selected Awards

  • 2012 The Haile T. Debas Academy of Medical Educators Excellence in Teaching Award
  • 2007-2012 NIH Mentored Clinical Scientist Development Award
  • 1996 Klaus R. Unna Award, for outstanding research accomplishments as a graduate student
  • 1990 University of Zagreb Chancellor’s Award, for outstanding academic performance as a medical student

Additional Information

Marta Margeta, MD, PhD
  • Associate Professor, Medical Director of Neuromuscular Laboratory, Associate Director of Undergraduate Pathology Education
  • Pathology
  • Neuropathology

Specialty Area

Neuroscience Research; Neuromuscular Pathology

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Marta Margeta, MD, PhD
  • Pathology, Box 0511
  • 513 Parnassus Avenue, Room HSW-514
  • San Francisco, CA 94143

Web Sites

Other UCSF Organizational Association(s)

  • Biomedical Sciences (BMS) Graduate Program

Hospital Affiliation(s)

  • Moffitt-Long
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