Marta Margeta, MD, PhD
Research and Clinical Interests
The long-term goal of our basic research is to elucidate how ion channel signaling and synaptic plasticity contribute to the selective vulnerability of different cell populations in the brain, thus influencing onset and/or progression of different neurologic disorders. We use a combination of different approaches (molecular and cell biology, immunohistochemistry, in situ hybridization, imaging, biochemistry, and electrophysiology) to investigate two distinct but related areas: (1) the function of intrinsic antioxidant signaling in the brain and skeletal muscle and (2) the role of autophagy impairment in neurologic disease pathogenesis.
The goal of our translational research is to improve tissue-based diagnostics of neurologic disorders; our current focus is on development of new immunohistochemical tools for pathologic diagnosis of neuromuscular disorders.
Selected Publications
- Habas A., Wang X., and Margeta M. Neuronal activity regulates astrocytic Nrf2 signaling. In revision (2012)
- Lee H.S., Daniels B.H., Salas E., Bollen A.W., Debnath J., and Margeta M. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: A case-control study. PloS ONE 7:e36221 (2012)
- Chandiramani N, Wang X, and Margeta M. Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line. PLoS ONE 6: e14485 (2011)
- Margeta M., Connolly A.M., Widner T.L., Pestronk A., and Moore S.A.: Cardiac pathology exceeds skeletal muscle pathology in two cases of limb-girdle muscular dystrophy type 2I. Muscle Nerve, 40:883-889 (2009)
- Layzer R., Lee H., Iverson D., and Margeta M..: Dermatomyositis with inclusion body myositis pathology. Muscle Nerve, 40:469-71 (2009)
Selected Awards
- 2007-2012 NIH Mentored Clinical Scientist Development Award
- 1997-2000 NIH Institutional Research Service Award
- 1996 Klaus R. Unna Award, for outstanding research accomplishments as a graduate student
- 1996 AFAR/Glenn Foundation Scholarship for Research in the Biology of Aging
- 1993-1994 University of Illinois Graduate College Fellowship
- 1990 University of Zagreb Chancellor’s Award, for outstanding academic performance as a medical student
Additional Information
- Assistant Professor, Director of Neuromuscular Pathology Service, Medical Director of Laboratory for Neuromuscular Special Studies
- Pathology
- Neuropathology
Specialty Area
Neuroscience Research; Neuromuscular Pathology
Contact Information
- Marta.Margeta@
ucsf.edu - Phone: 415-514-0228
- Fax: 415-514-3165
- UCSF Department of Pathology
- 513 Parnassus Avenue
- Room HSW-514, Box 0511
- San Francisco CA 94143-0511
Web Sites
Other UCSF Organizational Association(s)
- Biomedical Sciences (BMS) Graduate Program
Hospital Affiliation(s)
- Moffitt-Long