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Lab Manual for Moffitt-Long and Mount Zion

Lab Manual for SFGH

Internal Resources

Matthew Krummel, PhD

Research and Clinical Interests

Our research projects are aimed at understanding the molecular and cellular regulation of lymphocyte activation. We use real-time microscopic methods to image the dynamic movement of lymphocyte receptors during antigen recognition. We also design, build, and exploit emerging tools to study how collections of immune cells cooperate and are regulated in the lung during asthma and damage and in immunoevasive tumors.

Selected Publications

  • Nussbaum, J.C., Van Dyken, S.J., von Moltke, J., Cheng, L.E., Mohapatra, A., Molofsky, A.B., Thornton, E.E., Krummel, M.F., Chawla, A., Liang, H.E., Locksley, R.M. 2013. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10;502(7470):245-248. doi: 10.1038/nature12526.
  • Jacobelli, J., Estin Matthews, M., Chen, S., Krummel, M.F. 2013. Activated T Cell Trans-Endothelial Migration Relies on Myosin-IIA Contractility for Squeezing the Cell Nucleus through Endothelial Cell Barriers.PLoS One. 2013 Sep 19;8(9):e75151. doi: 10.1371/journal.pone.0075151.
  • Gérard, A., Khan, O., Beemiller, P., Oswald, E., Hu, J., Matloubian, M., Krummel, M.F. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Mar 10. doi: 10.1038/ni.2547.
  • Gérard, A., Beemiller, P., Friedman, R.S., Jacobelli, J., Krummel, M.F. 2013. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan;251(1):80-96. doi: 10.1111/imr.12021.
  • Cheng, L.E., Hartmann, K., Roers, A., Krummel, M.F., Locksley, R.M. 2013. Perivascular Mast Cells Dynamically Probe Cutaneous Blood Vessels to Capture Immunoglobulin E. Immunity. Jan 24;38(1):166-75. doi: 10.1016/j.immuni.2012.09.022. Epub 2013 Jan 3.

Selected Awards

  • 2009-2012: Fellow of the American Asthma Foundation
  • 2005-2010: Leukemia and Lymphoma Foundation, Career Award
  • 2004-2007: Investigator Award, Cancer Research Institute.
  • 1997-2000: NRSA Postdoctoral Fellowship, National Institutes of Health.
  • 1996-1997: Postdoctoral Fellowship, Juvenile Diabetes Foundation International.
  • 1998: PATENT: J.P.Allison, D.R.Leach, and M.F. Krummel. Blockade of T Lymphocyte Down-Regulation Associated with CTLA-4 Signaling. US Patent 5,811,097.
  • 1987: Summer Undergraduate Research Fellowship, Howard Hughes Medical Institute.

Additional Information

Matthew Krummel, PhD
  • Professor
  • Pathology

Specialty Area

Immunology

Contact Information

  • 513 Parnassus Avenue
  • Room HSW-512, Box 0511
  • San Francisco, CA 94143-0511

Web Site

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