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Lab Manual for Moffitt-Long and Mount Zion

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Internal Resources

Eric J. Huang, MD, PhD

Research and Clinical Interests

Developmental neurobiology, Pediatric neuropathology, Genetic mechanisms and animal models of germinal matrix hemorrhage and adult-onset neurodegeneration

Selected Publications

  • Wiggins, A.K., Wei, G., Doxakis, E., Wong, C., Tang, A.A., Zeng, K., Luo, E.J., Neve, R.L., Reichardt, L.F. and Huang, E.J. Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. J Cell Biol 167 (2): 257-267, 2004.
  • Doxakis, E., Huang, E.J. and Davies, A.M. Homeodomain interacting protein kinase 2 (HIPK2) regulates apoptosis in developing sensory and sympathetic neurons. Curr Biol 14(19): 1761-1765, 2004.
  • Zhang, J., Pho, V., Bonasera, S.J., Holzmann, J., Helmuth, J., Tang, A.A., Janak, P.H., Tecott, L.H. and Huang, E.J. Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nature Neuroscience 10:77-86, 2007 [Featured in News & Views].
  • Wei, G., Ku, S., Saito, S., Tang, A.A., Mao, J.H., Appella, E., Balmain, A. and Huang, E.J. HIPK2 represses beta-catenin-mediated cyclin D1 transcription: role in epidermal stem cells and tumorigenesis. Proc Natl Acad Sci (USA) 104: 13040-13045, 2007.
  • Tang, M., Miyamoto, Y. and Huang, E.J. Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development 136: 2027-2038, 2009 [Featured Article].
  • Huang, E.J., Zhang, J., Geser, F., Trojanowski, J.Q., Strober, J.B., Dickson, D.W., Brown, R.H., Jr., Shapiro, B.E. and Lomen-Hoerth, C. Extensive FUS-immunoreactive Pathology in Juvenile amyotrophic lateral sclerosis with Basophilic Inclusions. Brain Pathology 20: 1069-76, 2010.
  • Tang, M., Villaescusa, J.C., Luo, S.X., Guitarte, C., Lei, S., Miyamoto, Y., Maketo, M.M., Arenas, E. and Huang, E.J. Interactions of Wnt/b-catenin signaling and sonic hedgehog regulate theneurogenesis of midbrain dopamine neurons. J Neurosci 30: 9280-9, 2010.
  • Reyes, N.A., Fisher, J.K., Austgen, K., VandenBerg, S., Huang, E.J. and Oakes, S.A. Blocking the mitochondrial apoptotic pathway protects against neurodegeneration. J Clin Invest 120: 3673-9, 2010.
  • Chalazonitis, A., Tang, A.A., Shang, Y., Pham, T.D., Hsieh, I., Setlik, W., Gershon, M.D. and Huang, E.J. Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopamine Neurons and Glia via BMP Signaling. J Neurosci 31: 13746 –13757, 2011. (Selected for Cover Art)

Selected Awards

  • 1990-91 Frank Lappin Horsfall, Jr. Fellowship, Sloan-Kettering Cancer Center
  • 1991 Vincent du Vigneaud Award of Excellence, Cornell University
  • 1997-99 Postdoctoral Fellowship for Physicians, Howard Hughes Medical Institute
  • 1998 & 2004 Weil Award for the best paper in Experimental Neuropathology, AANP Annual Meeting
  • 1999 Advanced Career Development Award, Dept of Veterans Affairs
  • 2000 Young Investigator Award, NCIRE & SFVAMC
  • 2000-07 Merit Award, Dept of Veterans Affairs
  • 2000-05 Presidential Early Career Award for Scientists and Engineers (PECASE), Dept of Veterans Affairs
  • 2002-07 Independent Scientist Award NINDS, NIH
  • 2005 Dean’s Prize for Research, UCSF SOM, Medical Student Mentored: Stephen Ku
  • 2009-2014 Mid-career Investigator Award, NCRR/NIH

Additional Information

Eric J. Huang, MD, PhD
  • Professor
  • Pathology
  • Neuropathology

Specialty Area

Pediatric Neuropathology and Developmental Neurobiology

Contact Information

  • UCSF Department of Pathology
  • 513 Parnassus Avenue
  • Room HSW-450E, Box 0502
  • San Francisco, CA 94143-0502

Web Site

Other UCSF Organizational Association(s)

  • Program in Biological Science (PIBS)
  • Neuroscience Graduate Program
  • Biomedical Sciences (BMS) Program

Hospital Affiliation(s)

  • UCSF Moffitt-Long Hospital
  • San Francisco Veterans Administration Medical Center
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