Bradley A. Stohr, MD, PhD
Research and Clinical Interests
The research in my laboratory focuses on the telomere biology of human cancers. Telomeres are nucleoprotein structures that protect the ends of linear chromosomes. Telomeres shorten with each cell division, ultimately resulting in deprotection of the chromosome ends. Telomeric deprotection serves a tumor-suppressive function by initiating senescence and/or apoptosis in inappropriately dividing cells. However, deprotected telomeres frequently fuse together, resulting in genome instability that can promote tumorigenesis. The cellular context determines whether it is the tumor-suppressive or tumor-promoting role of the dysfunctional telomere that predominates. The long-term goal of my laboratory is to understand how different types of telomere dysfunction provoke these diverse cellular responses. This knowledge will provide insight into the origins and progression of human cancers and suggest novel strategies for telomere-based therapeutic approaches.
- Stohr BA, Xu L, Blackburn EH. 2010. The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. Molecular Cell. In press.
- Stohr BA, Blackburn EH. 2008. ATM is a key mediator of mutant telomerase RNA cytotoxicity in human cancer cells. Cancer Research 68:5309-17.
- Stohr BA, Kreuzer KN. 2002. Coordinated repair of DNA ends during double-strand break repair in bacteriophage T4. Genetics 162:1019-1030.
- George JW*, Stohr BA*, Tomso DJ, Kreuzer KN. 2001. The tight linkage between DNA replication and double-strand break repair in bacteriophage T4. PNAS 98:8290-8297. *co-first authors
- Stohr BA, Kreuzer KN. 2001. Repair of topoisomerase-mediated DNA damage in bacteriophage T4. Genetics 158:19-28.
- 2009-present: Mentored Clinical Scientist Development Award (K08)
- 2005-2008: American Cancer Society Postdoctoral Fellowship
- 2005: Ruth L. Kirschstein Postdoctoral Fellowship (declined)
- 1996-2003: Medical Scientist Training Program Fellowship
- 1995: Sigma Xi Honor Society 1995
- 1995: Phi Beta Kappa Honor Society
- Assistant Professor
- Cancer Research
- Autopsy Pathology
- Phone: 415-476-6729
- Fax: 415-514-0878
- 513 Parnassus Avenue
- Room HSW-425, Box 0502
- San Francisco, CA 94143-0502