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Arie Perry, MD

Research and Clinical Interests

My clinical interests focus most heavily on surgical neuropathology, especially in terms of its application towards neuro-oncology. As a diagnostic neuropathologist with a focus on CNS tumors, I am primarily involved in translational research with the primary goal of developing new diagnostic and prognostic markers, which can be utilized in the clinical management of brain tumor patients. In order to achieve this goal, my lab has applied immunohistochemical, molecular cytogenetic, and genomic screening techniques primarily towards the study of gliomas, meningiomas, and primitive pediatric malignancies. I have been particularly interested in improved classification and grading schemes as well as the identification of molecular genetic markers associated with tumorigenesis, malignant progression, and/or biologic behavior. I collaborate with a number of clinical and scientific researchers both within and outside UCSF and it is our hope that the markers we identify will improve patient management and lead to the development of novel therapeutic approaches. I also maintain a private consultation service for difficult surgical neuropathology cases obtained from the U.S. and abroad, particularly brain tumors.

Selected Publications

  • Perry A, Brat DJ (textbook editors). Practical Surgical Neuropathology. Elsevier/Churchill Livingstone, Philadelphia, PA 2010.
  • Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM. Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol 21: 1455-1465, 1997.
  • Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC. “Malignancy” in meningiomas: a clinicopathologic study of 116 patients. Cancer 85:2046-56, 1999.
  • Smith JS, Perry A (co-first author), Borell TJ, Lee HK, O’Fallon J, Hosek SM, Kimmel D, Yates A, Burger PC, Scheithauer BW, Jenkins RB. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol 18:636-45, 2000.
  • Perry A, Aldape KD, George DH, Burger PC. Small cell astrocytoma: An aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. Cancer 101:2318-26, 2004.
  • Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Res 65:7121-26, 2005.
  • Miller CR, Dunham CP, Scheithauer BW, Perry A. Significance of necrosis in grading of oligodendroglial neoplasms: A clinicopathological and genetic study of newly-diagnosed high-grade gliomas. J Clin Oncol 24:5419-26, 2006.
  • Miller CR, Perry A. Glioblastoma: Morphologic and molecular genetic diversity. Arch Pathol Lab Med 131:397-406, 2007.
  • Perry A, Miller CR, Gujrati M, Scheithauer BW, Casavilca Zambrano S, Jost SC, Raghavan R, Qian J, Cochran EJ, Huse JT, Holland EC, Burger PC, Rosenblum MK. Malignant gliomas with primitive neuroectodermal tumor-like components: A clinicopathologic and genetic study of 53 cases. Brain Pathol 19:81-90, 2009.
  • Behdad A, Perry A. Central Nervous System Primitive Neuroectodermal Tumors: A Clinicopathologic and Genetic Study of 33 Cases. Brain Pathol 20:441-50, 2010.

Selected Awards

  • 1994: T. Moore Award, best presentation dealing with clinicopathologic correlations, International Congress of Neuropathology meeting
  • 1995: Mary Tom Award, best presentation dealing with clinicopathologic correlations, Canadian Association of Neuropathologists meeting
  • 1995-1997: American Brain Tumor Association Fellowship Award
  • 1999, 2002, 2004, 2007, and 2009: Distinguished Service Teaching Award, Washington University Medical School (WUSM)
  • 2002: Lucien J. Rubenstein Award, best presentation dealing with neuro-oncology, American Association of Neuropathologists meeting
  • 2005 and 2008: Professor of the Year Award, WUSM
  • 2006-now: America’s Top Doctors and America's Top Doctors for Cancer (Castle Connolly Medical Ltd.)
  • 2008: Elected to Alpha Omega Alpha (AOA), WUSM Chapter for recognition of faculty commitment to medical education

Additional Information

Arie Perry, MD
  • Professor of Pathology and Neurological Surgery; Director of Neuropathology; Director of Neuropathology Fellowship Training Program
  • Pathology
  • Neuropathology

Specialty Area

  • Surgical Neuropathology

Contact Information

  • 505 Parnassus Avenue
  • Room M551, Box 0102
  • San Francisco, CA 94143-0102

Web Site

Educational Links:

Hospital Affiliation(s)

  • UCSF Moffitt-Long Hospital
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