Steve Miller, MD, PhD
Research and Clinical Interests
I am interested in the use of molecular methods for diagnosis and monitoring of clinical infectious disease, particularly in immunocompromised and transplant patients. Conventional clinical testing often is unable to identify pathogens of interest in patient samples, and my research aims to develop methods to better identify infectious agents, which could improve patient care and public health. Projects include:
- Clinical evaluation and implementation of quantitative PCR measurements of viral illness (EBV, BK, JC, CMV) and multiplex identification of these agents in disease or symptom-specific panels.
- Development and evaluation of microarray-based platforms for microbial identification of viral, bacterial, fungal and parasitic pathogens based on the UCSF-developed Virochip assay.
- Prediction of bacterial resistance through genetic analysis, including selection of genetic elements for analysis, collection of bacterial strains, analysis for phenotypic resistance, and prospective collection of clinical samples for direct testing using microarray techniques.
Selected Publications
- Jolly ER, Chin CS, Miller S, Baghat MM, Lim KC, Derisi J, McKerrow JH. (2007) Gene expression patterns during adaptation of a parasite helminth to different environmental niches. Genome Biology 8(4): R65.
- Nadarajah R, Khan GY, Miller SA, Brooks, GF. (2007) Evaluation of a new generation line probe assay that detects both 5’ untranslated and core regions to genotype and subtype hepatitis C virus. American Journal of Clinical Pathology 128(2): 300-4.
- Molaem J, Ruan DT, Farkas RL, Shen WT, Gosnell JE, Miller S, Duh QY, Clark OH and Kebebew E. (2009) Hemolysis falsely decreases intraoperative parathyroid hormone levels. American Journal of Surgery 197(2): 222-6.
- Miller S, Barker C, Hao Y, Erle D, Barczak A, Fischer K, DeRisi J and Chiu C. (2008) Establishing a microarray test for pan-viral identification (Virochip) as a core laboratory resource at UCSF. American Journal of Clinical Pathology 130(3): 475.
- Bonham M and Miller S. (2009) Clinical comparison of 99th percentile and 10% CV cutoff values for four commercially available troponin I assays. LabMedicine 40(8): 470-3.
Selected Awards
- 2006 Paul E. Strandjord Young Investigator Award
- 2006-07 College of American Pathologists Foundation Scholar
- Assistant Professor and Director, UCSF Clinical Microbiology Laboratory
- Laboratory Medicine
- Infectious Disease/Microbial Pathogenesis
Specialty Area
- Molecular Microbiology
Contact Information
- Steve.Miller@
ucsfmedctr.org - Phone: 415-353-9630
- Pager: 415-443-4269
- Fax: 415-514-6050
- 185 Berry Street, Suite 290
- Box 0100
- San Francisco, CA 94107
Hospital Affiliation(s)
- UCSF Medical Center
- UCSF Childrens Hospital
- Mt. Zion Medical Center