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Philip J. Norris, MD

Research and Clinical Interests

My lab is focused on understanding the immune response to infectious diseases and blood transfusion. Active areas of infectious disease research include defining the role CD4+ T cells play in controlling HIV replication, how HIV causes CD4+ T cell loss, how T cells and T regulatory cells respond to acute West Nile virus infection, and whether or not influenza A infection causes bloodstream infection. To understand the immunology of blood transfusion we are studying the relationship between anti-HLA antibodies and acute lung injury, and are also exploring how donor white cells persist in some post-trauma transfusion recipients.

Selected Publications

  • Lanteri, MC, Heitman JW, Owen RE, Busch TA, Gefter N, Kiely N, Kamel HT, Tobler LH, Busch MP, and Norris PJ. Comprehensive analysis of West Nile virus T cell responses in human infection. J Infect Dis 197(9):1296-1306 (2008).
  • Norris PJ, Lee J-H, Carrick D, Gottschall JL, Lebedeva M, de Castro BR, Kleinman SH, Busch MP, for the National Heart, Lung, and Blood Institute (NHLBI) Retrovirus Epidemiology Donor Study-II (REDS-II). Long-Term in vitro Reactivity for Human Leukocyte Antigen Antibodies and Comparison of Detection Using Serum versus Plasma. Transfusion 49(2):243-251 (2009).
  • Lanteri MC, O’Brien KM, Cameron MJ, Purtha WE, Lund JM, Owen RE, Heitman JW, Custer B, Hirschkorn DF, Tobler LH, Kiely N, Prince HE, Ndhlovu LC, Nixon DF, Kamel HT, Kelvin DJ, Busch MP, Rudensky AY, Diamond MS, Norris PJ. Regulatory T cells control the development of symptomatic West Nile virus infection. J Clin Invest 119(11):3266-77 (2009).
  • Jackman RP, Heitman JW, Marschner S, Goodrich RP, Norris PJ. Understanding loss of donor white blood cell immunogenicity following pathogen reduction: mechanisms of action in UV illumination and riboflavin treatment. Transfusion 49(12):2686-99 (2009).
  • Owen RE, Heitman JW, Hirschkorn DF, Lanteri MC, Biswas HH, Martin JN, Krone MR, Deeks SG, Norris PJ and the NIAID Center for HIV/AIDS Vaccine Immunology. HIV+ elite controllers have low levels of HIV-specific T cell activation yet maintain strong, polyfunctional T cell responses AIDS 24(8):1095-105 (2010).

Selected Awards

  • 1985 National Merit Scholar
  • 1985 California Scholarship Federation Award
  • 1985 Bank of America Scholar’s Award
  • 1985 - 1989 James B. Black Award (Pacific Gas & Electric Co. 4 year scholarship)
  • 1985 - 1989 University of California Alumni Association Scholar
  • 1985 - 1989 University of California Chancellor’s Scholar
  • 1995 Letter of Commendation for Teaching Excellence, College of Physicians & Surgeons, Columbia University
  • 1999 Chairman, P&S Class of 1995
  • 2000 - 2005 Doris Duke Charitable Foundation Clinical Scientist Development Award
Philip J. Norris, MD
  • Adjunct Professor
  • Laboratory Medicine
  • Blood Systems Research Institute

Specialty Area

  • Immunology, infectious diseases

Contact Information

  • Blood Systems Research Institute
  • 270 Masonic Avenue
  • San Francisco, CA 94118

Web Site

Other UCSF Organizational Association(s)

Clinical Professor

  • Department of Medicine
  • Division of Infectious Diseases

Associate Director

  • Center for AIDS Research

Associate Director, BSRI

  • Blood Systems Research Institute

Hospital Affiliation(s)

  • San Francisco General Hospital & Trauma Center
  • Blood Centers of the Pacific
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