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Mark Seielstad, PhD

Research and Clinical Interests

Research in my lab straddles genetic epidemiology and population/anthropological genetics. The main goal is to identify human genetic variation altering the risk of complex human diseases involving immunity (e.g., autoimmunity and susceptibility to infectious diseases) and metabolism (e.g., type 2 diabetes). This puts an emphasis on genomic technologies such as genome-wide SNP genotyping, and next-generation sequencing to reveal and characterize polymorphisms in whole exome and whole genome data. Much of this work is carried out in geographically diverse human populations, which are also the subject of anthropological investigations that seek to characterize the global distribution of genetic variation. A particular emphasis is placed on sequencing and coalescence analysis of the Y chromosome and mtDNA, as well as cultural practices that alter demographic and selective regimes acting on the sex-specific lineages of these two DNA molecules.

Selected Publications

  • Plenge RM*, Seielstad M*, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili MSH, Chandrasekaran A, Davies LRL, Li W, Tan AKS, Bonnard C, Ong RTH, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK. Genome-wide association study in rheumatoid arthritis identifies TRAF1-C5 as a new susceptibility locus (2007). The New England Journal of Medicine 357:1199-209. *Equal contributions
  • Davila S, Hibberd ML, Dass RH, Wong HEE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F , van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff THM, Seielstad M (2008) Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis. PLoS Genetics 4:e1000218.
  • **HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, Edo J, Fuchareon S, Ghang H, Gojobori T, Han J, Ho SF, Hoh BP, Huang W, Inoko H, Jha P, Jinam TA, Jin L, Jung J, Kangwanpong D, Kampuansai J, Kennedy GC, Khurana P, Kim HL, Kim K, Kim S, Kim WY, Kimm K, Kimura R, Koike T, Kulawonganunchai S, Kumar V, Lai PS, Lee JY, Lee S, Liu ET, Majumder PP, Mandapati KK, Marzuki S, Mitchell W, Mukerji M, Naritomi K, Ngamphiw C, Niikawa N, Nishida N, Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon HB, Phipps ME, Png E, Sakaki Y, Salvador JM, Sandraling Y, Scaria V, Seielstad** M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, Suryadi H, Suzuki Y, Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang Y, Wang H, Wu JY, Xiao H, Xu S, Yang JO, Shugart YY, Yoo HS, Yuan W, Zhao G, Zilfalil BA; Indian Genome Variation Consortium. (2009) Mapping human genetic diversity in Asia. Science. 326:1541-5. ** corresponding author
  • McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK; NIDDK IBD Genetics Consortium, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad** M. (2010) Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 42:332-7.

Selected Awards

  • 1992-93: National Institutes of Health Genetics Trainee, Harvard University
  • 1993-96: National Science Foundation Predoctoral Fellow
  • 2000: National Research Service Award, National Institute of General Medical Sciences (F32 GM20425-01) (declined)
  • 2000-02: Principal Investigator, Research Career Award, U.S. National Human Genome Research Institute (K22 HG00053-01; US$1,047,678) (2000-2002)

Additional Information

Mark Seielstad, Ph.D.
  • Associate Professor, Dept. of Laboratory Medicine, UCSF
  • Laboratory Medicine

Specialty Areas

  • Human Genetics

Contact Information

  • Blood Systems Research Institute
  • 270 Masonic Avenue
  • San Francisco CA 94118

Other UCSF Organizational Association(s)

  • Institute for Human Genetics
  • Biomedical Sciences Graduate Program
  • Biological and Medical Informatics Graduate Program

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