Michael S. McGrath, MD, PhD

Research and Clinical Interests

Translational research in defining the role macrophages play in the pathogenesis of chronic human disease. “Sequential Pathogenesis” model.
Development of macrophage targeted therapeutics, interfacing UCSF research program with private industry.
Facilitation of collaborative research through establishment of an international AIDS and cancer specimen bank/resource.

Zenger E, Abbey NW, Weinstein MD, Gofman I, Millward C, Gascon R, Elbaggari A, Herndier BG, McGrath MS. Injection of human primary effusion lymphoma cells or associated macrophages into SCID mice causes murine lymphomas. Cancer Research 62:5536-42; 2002.
Gascon RL, Narvaez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, McGrath MS. Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 cell apoptosis and CD4 cell depletion. JAIDS 30(2):146-153; 2002.
Mack KD, Jin X, Kapp L, Wei R, Abbey NW, Elbaggari A, Liu Y, Herndier BG, McGrath MS. HIV insertions within and proximal to host cell genes are a common finding in AIDS-related diseased tissues containing high levels of HIV p24 antigen expression. JAIDS 33(3):308-320; 2003.
Zhang RZ, Gascon R, Miller RG, Gelinas D, Mass J, Hadlock K, Jin X, Reis J, Narvaez A, McGrath MS. Evidence for systemic immune system alterations in sporadic Amyotrophic Lateral Sclerosis (sALS). Journal of Neuroimmunology, 159:215-224; 2005.
Salemi M, Lamer S, Yu S, Oliveira T, Fitch W, McGrath MS. HIV-1 Phylodynamic analysis in distinct brain compartments provides a model for the neuropathogenesis of AIDS. J Virol, Sept 17, 2005.

1973 Third Annual Livermore Award for Outstanding Student in Hematologic Research, University of Minnesota Medical School
1974 summa cum laude in Biology
1990 Outstanding Speaker Award, American Association for Clinical Chemistry
1999 - 2000 Mercatur Scholar, University of Heidelberg, Germany