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Lab Manual for Moffitt-Long and Mount Zion

Lab Manual for SFGH

Internal Resources

Lynn Pulliam MS, PhD

Research and Clinical Interests

My laboratory is interested in neuroinflammation and HIV dementia. We have used HIV seropositive patient monocyte/macrophages (M/M) and gene expression microarrays to develop a phenotype predictive of HIV dementia. Several new proteins discovered from these microarrays have been identified and are being shown to facilitate HIV infection. These gene/proteins have been found to correlate with MRS brain metabolites in recent studies. In addition, the laboratory is looking at HIV with hepatitis C (HCV) coinfection and cognitive impairment. We have identified several gene/biomarkers that correlate with cognitive impairment in coinfected individuals. New studies include looking at monocyte-derived miRNAs within exosomes as facilitators of neural cell dysfunction.

Selected Publications

  • Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J and Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in HAART-treated subjects with HIV-1 infection. J Neurovirol 16:115-24, 2010
  • Rempel H, Sun B, Calosing C, Pillai S, Pulliam L. Interferon-α drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS 24:1-9, 2010.
  • Pulliam L, Remel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in MRS metabolite concentrations. AIDS 25:1721-6, 2011.
  • Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr 62:190-6, 2013.
  • Rempel H, Sun B, Calsoing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV / HCV coinfection correlates with cognitive impairment. PlosOne e55776, 2013.
  • Pulliam L. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV infection. Current HIV Research, in press 2013.
  • Professor in Residence, Chief, Microbiology (VAMC)
  • Laboratory Medicine
  • Clinical Laboratory

Specialty Area

  • Microbiology

Contact Information

  • Veterans Affairs Medical Center
  • 4150 Clement St., (113A)
  • San Francisco, CA 94121

Hospital Affiliation(s)

  • Veterans Affairs Medical Center
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