Lynn Pulliam MS, PhD
Research and Clinical Interests
My laboratory is interested in neuroinflammation and HIV dementia. We have used HIV seropositive patient monocyte/macrophages (M/M) and gene expression microarrays to develop a phenotype predictive of HIV dementia. Several new proteins discovered from these microarrays have been identified and are being shown to facilitate HIV infection. These gene/proteins have been found to correlate with MRS brain metabolites in recent studies.In addition, the laboratory is looking at HIV infection and aging by studying HIV and its proteins and how they can modulate amyloid beta production in the brain.
Selected Publications
- Pulliam L, Sun B, Rempel H Martinez PM, Hoekman JD, Rao RJ, Frey II WH and Hanson LR.Intranasaal Tat alters gene expression in the mouse brain. J NeuroimmunPharm2:87-92, 2007.
- Rempel H, Calosing C, Sun B, Pulliam L. Interferon-induced expression of sialoadhesin on monocytes enhances HIV-1 infectivity. PlosOne. e1967 3:1-9 2008.
- Pulliam L. HIV regulation of amyloid beta production.J NeuroimmunePharmacol4:213-17, 2009.
- Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J and Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in HAART-treated subjects with HIV-1 infection. J Neuroviro. 16:115-24,2010.
- Rempel H, Sun B, Calosing C, Pillai S and Pulliam L. Interferon-α drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS24:1415-23, 2010.
- Professor in Residence, Chief, Microbiology (VAMC)
- Laboratory Medicine
- Clinical Laboratory
Specialty Area
- Microbiology
Contact Information
- Lynn.Pulliam@
ucsf.edu - Phone: 415-221-4810 ext. 6490
- Pager: 415-280-3669
- Fax: 415-379-5647
- Veterans Affairs Medical Center
- 4150 Clement St., (113A)
- San Francisco, CA 94121
Hospital Affiliation(s)
- Veterans Affairs Medical Center