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Lab Manual for Moffitt-Long and Mount Zion

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Internal Resources

Jingwei Yu, PhD, MM

Research and Clinical Interests

Genomic and epigenetic analysis of cancer and chromosome disorders, development of chromosomal and molecular markers for clinical diagnosis.

Selected Publications

  • Yu J, Zhang Y, Qi Z, Kurtycz D, Vacano G, Patterson D. Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. Gene Expr, 2008;14(3):173-82.
  • Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A, May/29/2009.
  • Ye L, Chang JC, Lin C, Qi Z, Yu J and Kan YW. Generation of induced pluripotent stem cells using site-specific integration with phage integrase. Proc Natl Acad Sci U S A, 11/2010;107(45):19467-72.
  • Ohi Y, Qin H, Hong C, Qi Z, Blouin L, Polo J, Guo T, Downey S, Hebrok M, Hochedlinger K, Yu J, Costello J, Song JS and Ramalho-Santos M. Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells. Nat Cell Biol. 2011 May;13(5):541-9. Epub 2011 Apr 17.
  • Lu CM, Zhou L, Feng S, Kohn PH, Qi Z and Yu J. Presence of complex t(6;9;22;15) four-way chromosome rearrangements plus a rare t(1;6) translocation does not affect the response to imatinib therapy in chronic myelogenous leukemia. Leukemia and Lymphoma. 2011 November; 52(11):2182-4.
  • Huang V, Place RF, PortnoyV, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J and Li LC. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Research, 2012 February: 40(4):1695-1707.
  • Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, Yeh R-F, Hebrok M and Ramalho-Santos M. Transcriptional Analysis of Pluripotency Reveals the Hippo Pathway as a Barrier to Reprogramming. Human Molecular Genetics. 2012 May 1;21(9):2054-67.
  • Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J and Kan YW. Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. Stem Cells Trans Med. 2013 (in press).
  • Huang V, Zheng J, Qi Z, Wang J, Place RP, Yu J, Li H and Li LC. Ago1 interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells. PLoS Genetics, 2013 (in press).
  • Professor of Clin Lab, Cytogenetics Laboratory Director
  • Laboratory Medicine

Specialty Area

  • Cytogenetics

Contact Information

  • 185 Berry Street, Suite 290
  • San Francisco, CA 94107

Hospital Affiliation(s)

  • UCSF Medical Center
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