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Gary A. Jarvis, PhD

Research and Clinical Interests

My research interests include: 1) Regulation of complement activation by blood-borne Gram-negative bacteria; 2) Development of vaccines for meningococcal meningitis and gonorrhea; 3) Complement deficiencies and susceptibility to bacterial sepsis; 4) Role of innate immune receptors in Gram-negative bacterial infections.

Selected Publications

  • Liu, M., C. M. John, and G. A. Jarvis. 2014. Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. J. Immunol. 192:1768-1777.
  • Liu, M., C. M. John, and G. A. Jarvis. 2010. Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways. J. Immunol. 185:6974–6984.
  • Bingham, D., C. M. John, S. S. Panter, and G. A. Jarvis. 2011. Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures. Brain Res. Bull. 85:403-409.
  • John, C. M., M. Liu, N. J. Phillips, Z. Yang, C. R. Funk, L. I. Zimmerman, J. M. Griffiss, D. C. Stein, and G. A. Jarvis. 2012. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect. Immun. 80:4014-4026.
  • Bingham, D., C. M. John, J. Levin, S. S. Panter, and G. A. Jarvis. 2013. Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain. J. Neuroimmunol. 256:28-37.
Gary A. Jarvis, PhD
  • Professor
  • Laboratory Medicine
  • Infectious Diseases

Specialty Area

  • Gram-negative bacterial infections

Contact Information

  • VA Medical Center,
  • Dept. 111W1, 4150 Clement Street,
  • San Francisco, CA 94121
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