Edward Thornborrow, MD, PhD
Research and Clinical Interests
My interests include the diagnosis and study of hematologic malignancies with an emphasis on identifying novel sets of markers that provide clinically relevant diagnostic and prognostic information. In addition, I am interested in the development and implementation of new laboratory testing methodologies and quality improvement procedures that allow us to better serve our patient population.
- Thornborrow, EC, Maurer, M, and Manfredi, JJ. Electrophoretic Mobility Shift Analysis of the DNA binding of Tumor Suppressor Gene Products, in Tumor Suppressor Genes, Methods and Protocols, Methods in Molecular Medicine Series, Wafik S. El-Deiry (ed.), Humana Press, USA, 223:87-100, 2003.
- Thornborrow, EC, Patel, S, Mastropietro, AE, Schwartzfarb, EM, and Manfredi, JJ. A Conserved Intronic Response Element Mediates DirectP53-dependent Transcriptional Activation of Both the Human and Murine BAX Genes, Oncogene. 21:990-999, 2002.
- Thornborrow, EC, and Manfredi, JJ. The Tumor Suppressor Protein P53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter, Journal of Biological Chemistry. 276: 15598-15608, 2000.
- Thornborrow, EC, and Manfredi, JJ. One Mechanism for Cell Type-specific Regulation of the BAX promoter by the Tumor Suppressor p53 is Dictated by the p53 Response Element, Journal of Biological Chemistry. 274: 33747-33756, 1999.
- Director, UCSF Clinical Laboratories at Mt. Zion and Mission Bay
- Laboratory Medicine
- Phone: (415) 476-7888
- Pager: (415) 443-1277
- Fax: (415) 476-7973
- University of California, San Francisco
- 1825- 4th Street, Suite M2339, Rm M2302
- San Francisco, CA 94158
- Moffitt-Long Hospital
- Mt. Zion Medical Center