UCSF Navigation Bar

UCSF Departments of Pathology & Laboratory Medicine Home Page

Lab Manual for UCSF Clinical Laboratories

Lab Manual for SFGH

Internal Resources

Ari B. Molofsky, MD PhD

Research and Clinical Interests

The Molofsky research laboratory studies allergic, type 2 immune responses in tissue physiology and pathology. We are particularly focused on group 2 innate lymphoid cells (ILC2) and tissue regulatory T (Treg) cells in models of metabolic health and disease, including obesity and type 2 diabetes. Our long-term goals are to understand the regulation, interactions, cytokine production, and metabolic impact of allergic immunity in a range of metabolic tissues, infectious and autoimmune models, and human disease. Clinically, Dr. Molofsky has a strong interest in flow cytometry and minimal residual disease detection.

Selected Publications

  • Molofsky, A.B., Van Gool, F., Liang, H.-E., Van Dyken, S.J., Nussbaum, J.C., Lee, J., Bluestone, J.A., and Locksley, R.M. (2015). Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity.
  • Molofsky, A.B., Savage, A.K., and Locksley, R.M. (2015). Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity 42, 1005–1019.
  • Guigas, B., and Molofsky, A.B. (2015). A worm of one's own: how helminths modulate host adipose tissue function and metabolism. Trends Parasitol. 1–7.
  • Van Gool, F.*, Molofsky, A.B*., Morar, M.M., Rosenzwajg, M., Liang, H.-E., Klatzmann, D., Locksley, R.M., and Bluestone, J.A. (2014). Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood 124, 3572–3576. *co-first
  • Molofsky, A.B., Nussbaum, J.C., Liang, H.-E., Van Dyken, S.J., Cheng, L.E., Mohapatra, A., Chawla, A., and Locksley, R.M. (2013). Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med 210, 535–549.
  • Wu, D., Molofsky, A.B., Liang, H.-E., Ricardo-Gonzalez, R.R., Jouihan, H.A., Bando, J.K., Chawla, A., and Locksley, R.M. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243–247.
  • Molofsky, A.B., Byrne, B.G., Whitfield, N.N., Madigan, C.A., Fuse, E.T., Tateda, K., and Swanson, M.S. (2006). Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med 203, 1093–1104.

Selected Awards

  • 2014-2019 NIH K08 Clinical Scientist Career Development Award
  • 2014-2015 UCSF Pilot for Junior Investigators REAC Award
  • 2006 Alpha Omega Alpha (AOA) Medical Honors Society, University of Michigan
  • 2006 Ward J. MacNeal Distinguished Dissertation Award, Microbiology/Immunology
  • 1999 The Dean's Honored Graduate in Molecular Biology, University of Texas
  • 1999 Phi Beta Kappa, University of Texas
Ari B. Molofsky, MD PhD
  • Assistant Professor, Assistant Director of Clinical Labs Immunology Section
  • Laboratory Medicine
  • Division: Hematology

Specialty Areas

  • Hematopathology
  • Immunology

Contact Information

Mailing/Shipping Address:

  • UCSF
  • Ari B. Molofsky, MD PhD
  • Laboratory Medicine, Box 0451
  • 513 Parnassus Avenue, Room HSW-1201U
  • San Francisco, CA 94143

Web Site

Other UCSF Organizational Association(s)

  • UCSF Diabetes Center, UCSF Biomedical Sciences Graduate Program, UCSF Immunology Program

Hospital Affiliation(s)

  • UCSF Medical Center
  • Moffitt-Long
UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center