Ari B. Molofsky, MD PhD
Research and Clinical Interests
The Molofsky research laboratory studies allergic, type 2 immune responses in tissue physiology and pathology. We are particularly focused on group 2 innate lymphoid cells (ILC2) and tissue regulatory T (Treg) cells in models of metabolic health and disease, including obesity and type 2 diabetes. Our long-term goals are to understand the regulation, interactions, cytokine production, and metabolic impact of allergic immunity in a range of metabolic tissues, infectious and autoimmune models, and human disease. Clinically, Dr. Molofsky has a strong interest in flow cytometry and minimal residual disease detection.
- Molofsky, A.B., Van Gool, F., Liang, H.-E., Van Dyken, S.J., Nussbaum, J.C., Lee, J., Bluestone, J.A., and Locksley, R.M. (2015). Interleukin-33 and Interferon-Î³ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity.
- Molofsky, A.B., Savage, A.K., and Locksley, R.M. (2015). Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity 42, 1005–1019.
- Guigas, B., and Molofsky, A.B. (2015). A worm of one's own: how helminths modulate host adipose tissue function and metabolism. Trends Parasitol. 1–7.
- Van Gool, F.*, Molofsky, A.B*., Morar, M.M., Rosenzwajg, M., Liang, H.-E., Klatzmann, D., Locksley, R.M., and Bluestone, J.A. (2014). Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood 124, 3572–3576. *co-first
- Molofsky, A.B., Nussbaum, J.C., Liang, H.-E., Van Dyken, S.J., Cheng, L.E., Mohapatra, A., Chawla, A., and Locksley, R.M. (2013). Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med 210, 535–549.
- Wu, D., Molofsky, A.B., Liang, H.-E., Ricardo-Gonzalez, R.R., Jouihan, H.A., Bando, J.K., Chawla, A., and Locksley, R.M. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243–247.
- Molofsky, A.B., Byrne, B.G., Whitfield, N.N., Madigan, C.A., Fuse, E.T., Tateda, K., and Swanson, M.S. (2006). Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med 203, 1093–1104.
- 2014-2019 NIH K08 Clinical Scientist Career Development Award
- 2014-2015 UCSF Pilot for Junior Investigators REAC Award
- 2006 Alpha Omega Alpha (AOA) Medical Honors Society, University of Michigan
- 2006 Ward J. MacNeal Distinguished Dissertation Award, Microbiology/Immunology
- 1999 The Dean's Honored Graduate in Molecular Biology, University of Texas
- 1999 Phi Beta Kappa, University of Texas
- Assistant Professor, Assistant Director of Clinical Labs Immunology Section
- Laboratory Medicine
- Division: Hematology
- See UCSF Directory
- Ari B. Molofsky, MD PhD
- Laboratory Medicine, Box 0451
- 513 Parnassus Avenue, Room HSW-1201U
- San Francisco, CA 94143
Other UCSF Organizational Association(s)
- UCSF Diabetes Center, UCSF Biomedical Sciences Graduate Program, UCSF Immunology Program
- UCSF Medical Center